Article (Scientific journals)
Cyclodextrins as a potential carrier in drug nebulization
Evrard, Brigitte; Bertholet, P.; Guéders, Maud et al.
2004In Journal of Controlled Release, 96 (3), p. 403-410
Peer Reviewed verified by ORBi
 

Files


Full Text
Evrard B JCR 2004.pdf.pdf
Author postprint (303.83 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Aerosols; Animals; Blood Urea Nitrogen; cyclodextrins; drug delivery; inhalation therapy; Excipients; lung; Inflammation/chemically induced/pathology; Mice; Pharmaceutical Preparations/administration & dosage; Surface Tension
Abstract :
[en] The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. (C) 2004 Elsevier B.V. All rights reserved.
Disciplines :
Chemistry
Pharmacy, pharmacology & toxicology
Author, co-author :
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Bertholet, P.
Guéders, Maud ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Flament, M. P.
Piel, Géraldine ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Delattre, Luc ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Gayot, A.
Leterme, P.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Cataldo, Didier  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement - Département des sciences biomédicales et précliniques
Language :
English
Title :
Cyclodextrins as a potential carrier in drug nebulization
Publication date :
2004
Journal title :
Journal of Controlled Release
ISSN :
0168-3659
eISSN :
1873-4995
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
96
Issue :
3
Pages :
403-410
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 May 2009

Statistics


Number of views
335 (26 by ULiège)
Number of downloads
720 (20 by ULiège)

Scopus citations®
 
68
Scopus citations®
without self-citations
61
OpenCitations
 
58

Bibliography


Similar publications



Contact ORBi