Reference : Neuroimmune connections in ovine pharyngeal tonsil: potential site for prion neuroinvasion
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/120065
Neuroimmune connections in ovine pharyngeal tonsil: potential site for prion neuroinvasion
English
Toppets, Vinciane mailto [Université de Liège - ULg > Département de morphologie et pathologie > Histologie >]
Piret, Joëlle mailto [Université de Liège - ULg > Département de morphologie et pathologie > Département de morphologie et pathologie >]
Kirschvink, Nathalie [ > > ]
Lantier, Frederic [ > > ]
Lantier, Isabelle [ > > ]
Berthon, Patricia [ > > ]
Daube, Georges mailto [Université de Liège - ULg > Département de sciences des denrées alimentaires > Microbiologie des denrées alimentaires >]
Massart, Laurent [ > > ]
Grobet, Luc mailto [Université de Liège - ULg > Département de morphologie et pathologie > Embryologie >]
Antoine, Nadine mailto [Université de Liège - ULg > Département de morphologie et pathologie > Histologie >]
17-Mar-2012
Cell & Tissue Research
Springer Science & Business Media B.V.
Yes (verified by ORBi)
International
0302-766X
1432-0878
New York
NY
[en] Sheep ; Scrapie ; Pharyngeal tonsi ; Innervation ; Follicular denritic cells
[en] Recent studies have proved the possible implication of nasal associated lymphoid tissues, mainly the pharyngeal tonsil, in prion pathogenesis. However, the mechanisms of this neuroinvasion are still being debated. To determine the potential sites for prion neuroinvasion inside the ovine pharyngeal tonsil, the topography of neurofilaments heavy (200 kDa) (NFH), neurofilaments light (70 kDa) (NFL) and glial fibrillar acidic protein (GFAP) was semi-quantitatively analysed inside the different compartments of the tonsil. The results showed that the most innervated areas were the interfollicular area and the connective tissue located beneath the respiratory epithelium. Even if the germinal centre of the lymphoid follicles was poorly innervated, the existence of rare follicular dendritic cell-nerve synapses inside the germinal centre indicates that this mechanism of neuroinvasion is possible but unlikely to be unique. The host PRNP genotype did not influence the pattern of innervation in these different tonsil compartments, unlike age: an increase of nerve endings in a zone of high trafficking cells beneath the respiratory epithelium occurred with ageing. A minimal age-related increase of innervation inside the lymphoid follicles was also observed. An increase in nerve fibre density around the lymphoid follicles, in an area rich in mobile cells able to transport PrPd, could ensure a more efficient infectivity, not in the early phase but in the advanced phase of lymphoinvasion after amplification of PrPd, or could act as direct site of entry during neuroinvasion.
http://hdl.handle.net/2268/120065

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