ORBi: Valat J P - A comparison of the efficacy and tolerability of meloxicam and diclofenac in the treatment of patients with osteoarthritis of the lumbar spine.

Reference : A comparison of the efficacy and tolerability of meloxicam and diclofenac in the treatme...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : General & internal medicine
	To cite this reference:	http://hdl.handle.net/2268/119897

Title :	A comparison of the efficacy and tolerability of meloxicam and diclofenac in the treatment of patients with osteoarthritis of the lumbar spine.
Language :	English
Author, co-author :	Valat, J P [> > > >]
	Accardo, S [> > > >]
	REGINSTER, Jean-Yves [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur]
	Wouters, Murielle [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques]
	Hettich, M [> > > >]
	Lieu, P L [> > > >]
Publication date :	2001
Journal title :	Inflammation Research
Publisher :	Springer Science & Business Media B.V.
Volume :	50
Issue/season :	Suppl 1
Pages :	S30-4
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	1023-3830
e-ISSN :	1420-908X
City :	Basel
Country :	Switzerland
Keywords :	[en] Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Cyclooxygenase Inhibitors/therapeutic use ; Diclofenac/adverse effects/therapeutic use ; Double-Blind Method ; Female ; Humans ; Lumbar Vertebrae ; Male ; Middle Aged ; Osteoarthritis/drug therapy ; Spinal Diseases/drug therapy ; Thiazines/adverse effects/therapeutic use ; Thiazoles/adverse effects/therapeutic use
Abstract :	[en] OBJECTIVE: The aim of this study was to evaluate the efficacy and tolerability of meloxicam compared with diclofenac in patients with osteoarthritis of the lumbar spine. SUBJECTS: 229 patients with radiologically confirmed osteoarthritis of the lumbar spine. TREATMENT AND METHODS: Once-daily meloxicam 7.5 mg tablet or diclofenac 100 mg slow release tablet. Efficacy and tolerability parameters were assessed at baseline and after 3, 7 and 14 days of treatment. RESULTS: The two drugs had equal short-term efficacy, with pain on motion of lumbar spine significantly (p<0.05) decreased at Day 3. Secondary efficacy variables were also significantly improved at Days 3, 7 and 14. There were no statistically significant differences between the two drugs, although the global tolerability of meloxicam was significantly better than for diclofenac, as assessed by the investigators (p = 0.0072) and the patients (p = 0.049). CONCLUSIONS: Meloxicam and diclofenac were equivalent in relieving the acute pain associated with osteoarthritis of the lumbar spine. However, meloxicam was much better tolerated.
Permalink :	http://hdl.handle.net/2268/119897

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