Reference : A comparison of the efficacy and tolerability of meloxicam and diclofenac in the treatme...
Scientific journals : Article
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/119897
A comparison of the efficacy and tolerability of meloxicam and diclofenac in the treatment of patients with osteoarthritis of the lumbar spine.
English
Valat, J P [> > > >]
Accardo, S [> > > >]
REGINSTER, Jean-Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur]
Wouters, Murielle mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques]
Hettich, M [> > > >]
Lieu, P L [> > > >]
2001
Inflammation Research
Springer Science & Business Media B.V.
50
Suppl 1
S30-4
Yes (verified by ORBi)
International
1023-3830
1420-908X
Basel
Switzerland
[en] Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Cyclooxygenase Inhibitors/therapeutic use ; Diclofenac/adverse effects/therapeutic use ; Double-Blind Method ; Female ; Humans ; Lumbar Vertebrae ; Male ; Middle Aged ; Osteoarthritis/drug therapy ; Spinal Diseases/drug therapy ; Thiazines/adverse effects/therapeutic use ; Thiazoles/adverse effects/therapeutic use
[en] OBJECTIVE: The aim of this study was to evaluate the efficacy and tolerability of meloxicam compared with diclofenac in patients with osteoarthritis of the lumbar spine. SUBJECTS: 229 patients with radiologically confirmed osteoarthritis of the lumbar spine. TREATMENT AND METHODS: Once-daily meloxicam 7.5 mg tablet or diclofenac 100 mg slow release tablet. Efficacy and tolerability parameters were assessed at baseline and after 3, 7 and 14 days of treatment. RESULTS: The two drugs had equal short-term efficacy, with pain on motion of lumbar spine significantly (p<0.05) decreased at Day 3. Secondary efficacy variables were also significantly improved at Days 3, 7 and 14. There were no statistically significant differences between the two drugs, although the global tolerability of meloxicam was significantly better than for diclofenac, as assessed by the investigators (p = 0.0072) and the patients (p = 0.049). CONCLUSIONS: Meloxicam and diclofenac were equivalent in relieving the acute pain associated with osteoarthritis of the lumbar spine. However, meloxicam was much better tolerated.
http://hdl.handle.net/2268/119897

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