Reference : Treating gliomas with glucocorticoids: from bedside to bench
Scientific journals : Letter to the editor
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/11924
Treating gliomas with glucocorticoids: from bedside to bench
English
Piette, Caroline mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement]
Munaut, Carine mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Deprez, Manuel mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Dec-2006
Acta Neuropathologica
Springer Verlag
112
6
651-664
Yes (verified by ORBi)
International
0001-6322
1432-0533
New York
NY
[en] glucocorticosteroid ; glioma ; cell culture ; oedema ; angiogenesis
[en] Glucocorticoids are used in the treatment of gliomas to decrease tumour-associated oedema and to reduce the risk of acute encephalopathy associated with radiotherapy. However, the mechanisms by which glucocorticoids work are still largely unknown. In this paper, we survey the experimental and clinical evidence for the effects of glucocorticoids on tumour cell proliferation, apoptosis and sensitivity to chemotherapy, angiogenesis and vascular permeability. We then review current guidelines on the choice of molecule, dose and duration of glucocorticoid treatment for gliomas.
http://hdl.handle.net/2268/11924

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