Reference : Preparation of poly(D,L-lactide) nanoparticles assisted by amphiphilic poly(methyl metha...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/11914
Preparation of poly(D,L-lactide) nanoparticles assisted by amphiphilic poly(methyl methacrylate-co-methacrylic acid) copolymers
English
Gautier, Sandrine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Grudzielski, Nathalie [University of Liège (ULg) > > Biology and Strucutral Morphology Laboratory > >]
Goffinet, Gerhard mailto [University of Liège (ULg) > > Biology and Strucutral Morphology Laboratory > >]
Henry de Hassonville, Sandrine [University of Liège (ULg) > Department of Pharmacy > Pharmaceutical Technology Laboratory > >]
Delattre, Luc mailto [University of Liège (ULg) > Department of Pharmacy > Pharmaceutical Technology Laboratory > >]
Jérôme, Robert mailto [Université de Liège - ULg > > Centre d'études et de rech. sur les macromolécules (CERM) >]
2001
Journal of Biomaterials Science. Polymer Edition
VSP BV (filiale de l'Editeur Brill Academic Publishing)
12
4
429-450
Yes (verified by ORBi)
International
0920-5063
[en] self-assembly in solution ; organic nanoparticle
[en] When co-precipitated with amphiphilic copolymers from DMSO, poly(D,L-lactide) (PLA) can be readily converted into stable sub-200 nm nanoparticles by addition of an aqueous phase, free of any polymeric stabilizers such as poly(vinyl alcohol) or Poloxamer. In this work, the ability of random poly(methyl methacrylate-co-methacrylic acid) copolymers (PMMA-co-MA) to stabilize PLA nanoparticles was demonstrated, and the properties of PLA/PMMA-co-MA nanoparticles were investigated. When co-precipitated with PMMA-co-MA, PLA was totally converted into nanoparticles using a polymer concentration in DMSO (Cp) below 17.6 mg ml(-1), and a PMMA-co-MA proportion above a critical value depending on the content of MA repeating units (X). For instance, the lowest PMMA-co-MA proportion required was 0.9 mg mg(-1) PLA for X = 12%, and 0.5 mg mg(-1) PLA for X = 25% (for C(PLA) = 16 mg ml(-1) DMSO). The nanoparticle diameter was essentially independent of X, the proportion of PMMA-co-MA, and the PLA molecular weight, except for oligomers for which the nanoparticle diameter was smaller. It decreased when the organic phase was diluted (126 +/- 13 nm for Cp = 17.6 mg ml(-1), and 81 +/- 5 nm for C(P) = 5.6 mg ml(-1)). The time-dependence of the stability and the degradation of PLA/PMMA-co-MA nanoparticles was discussed. One of the main advantages of this technique is the ability to control surface properties and to bring functional groups to otherwise non-functionalized PLA nanoparticles. To illustrate this, a conjugate of PMMA-co-MA25 and biotin was synthesized, and used to prepare biotinylated nanoparticles that could be detected by fluorescence and transmission electron microscopy after infiltration into ligatured rat small intestine.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Researchers
http://hdl.handle.net/2268/11914
10.1163/156856201750195306
http://brill.publisher.ingentaconnect.com/content/vsp/bsp/2001/00000012/00000004/art00004

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Gautier_S_2001_J bio sci polymer ed_12_4_429.pdfNo commentaryAuthor postprint576.07 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.