Article (Scientific journals)
Endogenous Production of Specific Antibodies Does Not Decrease Hypocalcemic Response to Calcitonin in Young Rabbits
Reginster, Jean-Yves; Azria, M.; Lismonde, Stéphanie et al.
1992In Calcified Tissue International, 50, p. 518-20
Peer Reviewed verified by ORBi
 

Files


Full Text
Endogenous production of specific antibodies.pdf
Publisher postprint (347.88 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] In order to evaluate the potential inhibition of the acute anti-osteoclastic activity of salmon calcitonin (SCT) by specific antibodies (Ab), we compared the SCT-induced hypocalcemic effect in young male rabbits with significant titers of high affinity Ab and in matched animals without Ab. Immunization of rabbits was performed by repetitive s.c. injections of SCT and Freund adjuvant. Ab were present in four-fifths of SCT-treated rabbits (Ab+). Their titer varied from 0.8 x 10(-9) to 30 x 10(-9) M/liter and their constant of affinity from 0.97 x 10(9) to 4.2 x 10(9) L/M. Intravenous injection of 1 IU/kg SCT to Ab+ rabbits induced a significant decrease (P less than 0.01) of ionized serum calcium (Ca2+) after 30 minutes (mean +/- SD: -9 +/- 0.6%) and until the 240th minute of the test (-16.7 +/- 4.7%), with a maximum after 120 minutes (-22.6 +/- 2%). This was not significantly different from the hypocalcemic effect measured after the same procedure performed in matched animals without Ab (Ab-): significant decrease in Ca2+ (P less than 0.01) after 30 minutes (-8.2 +/- 2.2%), maximal after 150 minutes (-23.2 +/- 4.9%), and lasting until 210 minutes (-14.5 +/- 3.7%). We conclude that, in the particular model of the male young rabbit, specific anti-SCT Ab do not block or reduce the acute anti-osteoclastic activity of SCT.
Disciplines :
Rheumatology
Author, co-author :
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Azria, M.
Lismonde, Stéphanie ;  Centre Hospitalier Universitaire de Liège - CHU > Quartier accouchement NDB
Bleicher, M.
Franchimont, N.
Behhar, M.
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Franchimont, P.
Language :
English
Title :
Endogenous Production of Specific Antibodies Does Not Decrease Hypocalcemic Response to Calcitonin in Young Rabbits
Publication date :
June 1992
Journal title :
Calcified Tissue International
ISSN :
0171-967X
eISSN :
1432-0827
Publisher :
Springer, Germany
Volume :
50
Pages :
518-20
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 May 2012

Statistics


Number of views
42 (2 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
10
Scopus citations®
without self-citations
8
OpenCitations
 
6

Bibliography


Similar publications



Contact ORBi