Article (Scientific journals)
Effects of Etodolac on Human Chondrocytes Cultivated in Three Dimensional Culture
Henrotin, Yves; Bassleer, C.; Reginster, Jean-Yves et al.
1989In Clinical Rheumatology, 8 (Suppl 1), p. 36-42
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Abstract :
[en] Human chondrocytes in three-dimensional culture were incubated for up to 20 days in the presence of etodolac, a nonsteroidal anti-inflammatory drug which penetrates readily into the synovial fluid. Even at an etodolac concentration of 80 micrograms/ml, DNA synthesis, proteoglycan synthesis, and type-II collagen synthesis were unchanged. Collagenase production was also unaffected by etodolac (60 micrograms/ml). In contrast, prostaglandin E2 production was reduced by 84% in the presence of 60 micrograms/ml of etodolac. The 80 micrograms/ml concentration is 5 times that found in the serum of subjects treated with 200 mg of etodolac twice a day for 6 days, and 33 times the concentration in synovial fluid of arthritic patients treated with etodolac 200 mg twice a day for 7 days. These in vitro results indicate that anti-inflammatory levels of etodolac may not damage articular cartilage in vivo.
Disciplines :
Rheumatology
Author, co-author :
Henrotin, Yves  ;  Université de Liège - ULiège > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Bassleer, C.
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Franchimont, P.
Language :
English
Title :
Effects of Etodolac on Human Chondrocytes Cultivated in Three Dimensional Culture
Publication date :
March 1989
Journal title :
Clinical Rheumatology
ISSN :
0770-3198
eISSN :
1434-9949
Publisher :
Springer, Germany
Volume :
8
Issue :
Suppl 1
Pages :
36-42
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 May 2012

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