Reference : Risk factor of fetal chromosomal aberrations in the south of Vietnam

	Document type :	Scientific congresses and symposiums : Paper published in a journal
	Discipline(s) :	Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
	To cite this reference:	http://hdl.handle.net/2268/118678

Title :	Risk factor of fetal chromosomal aberrations in the south of Vietnam
Language :	English
Author, co-author :	To, Hong [Université de Liège - ULg > > > Doct. sc. médicales (Bologne)]
Publication date :	22-Apr-2012
Journal title :	European Federation of Societies for Ultrasound in Medicine and Biology
Pages :	224
On invitation :	Yes
Audience :	International
City :	Madrid
Country :	Spain
Event name :	The 24th EUROSON Congress
Event date :	du 22 au 24 avril 2012
Event organizer :	European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB)
Event place (city) :	Madrid
Event country :	Spain
Keywords :	[en] Fetal aneuploidy ; Trisomy 21 ; Ultrasonographic finding
Abstract :	[en] Objectives: The aim of this study is to find the risk factors of fetal chromosomal aberrations in order to classify a high risk pregnancy in our prenatal care unit. Material and methods: A prospective study was carried out during one year in our clinic. 523 cases of amniocentesis was followed up and evaluated the relation with abnormal result (fetal aneuploidies) and the risk factors such as advanced maternal age (≥ 35 years old), parity, habitation, positive triple test (≥ 1/250), fetal malformation history and abnormal signs in the first and second trimester scanning. Results: The incidence of fetal aneuploidy was 3.4% (18/523 [95%CI: 2.1-5.4%]) and the trisomy 21 showed the most common in these chromosomal aberrations (67%). The younger women (< 35 years old), nulliparous, positive triple test and abnormal ultrasonographic findings (included increased nuchal translucency [≥ 2.4mm], absent nasal bone in the first trimester scanning and/or echogenic nodule in ventricular) was identified as the risk factors of fetal aneuploidies (OR was 2.3 [95%CI: 0.8-6.7], 4.0 [95%CI: 1.4-13.2], 3.3 [95%CI: 0.3-33.5] and 9.4 [95%CI: 1.1-79.2], respectively). The abnormal ultrasonographic findings found a relation significantly with abnormal chromosomes (p=0.04). Conclusion: Abnormal ultrasonographic findings in the first and second trimester were the important markers for predicting fetal aneuploidy, especially trisomy 21.
Permalink :	http://hdl.handle.net/2268/118678

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