Reference : Hierarchical clustering of brain activity during human nonrapid eye movement sleep.
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/118328
Hierarchical clustering of brain activity during human nonrapid eye movement sleep.
English
Boly, Mélanie mailto [Université de Liège - ULg > Centre de recherches du cyclotron - Coma Science Group - Département des sciences cliniques > Neurologie > >]
Perlbarg, V [> > > >]
Marrelec, G [> > > >]
Schabus, M [> > > >]
Laureys, Steven mailto [Université de Liège - ULg > Centre de recherches du cyclotron - Coma Science Group > > >]
Doyon, J [> > > >]
Pelegrini-Issac, M [> > > >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Benali, H [> > > >]
2012
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
Yes (verified by ORBi)
International
0027-8424
1091-6490
Washington
DC
[en] Consciousness is reduced during nonrapid eye movement (NREM) sleep due to changes in brain function that are still poorly understood. Here, we tested the hypothesis that impaired consciousness during NREM sleep is associated with an increased modularity of brain activity. Cerebral connectivity was quantified in resting-state functional magnetic resonance imaging times series acquired in 13 healthy volunteers during wakefulness and NREM sleep. The analysis revealed a modification of the hierarchical organization of large-scale networks into smaller independent modules during NREM sleep, independently from EEG markers of the slow oscillation. Such modifications in brain connectivity, possibly driven by sleep ultraslow oscillations, could hinder the brain's ability to integrate information and account for decreased consciousness during NREM sleep.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fondation Médicale Reine Elisabeth ; European Sleep Research Grant
http://hdl.handle.net/2268/118328
10.1073/pnas.1111133109
www.pnas.org/cgi/doi/10.1073/pnas.1111133109

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