Reference : Statistical analysis of serum protein electrophoresis results in External Quality Ass...
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/11818
Statistical analysis of serum protein electrophoresis results in External Quality Assessment schemes
English
Zhang, Lixin mailto [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
Van Campenhout, Christel [Scientific Institute of Public Health > Department of Clinical Biology > > >]
Devleeschouwer, Nicole [Scientific Institute of Public Health > Department of Clinical Biology > > >]
Libeer, Jean-Claude [Scientific Institute of Public Health > Department of Clinical Biology > > >]
Albert, Adelin mailto [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique > >]
Mar-2008
Accreditation and Quality Assurance
Springer
13
3
149-155
Yes
International
0949-1775
1432-0517
Berlin / Heidelberg
Germany
[en] Electrophoresis ; EQA schemes ; Outliers ; Robust statistics
[en] The goal of External Quality Assessment (EQA)
schemes is to ensure that results obtained on a particular
specimen in a given clinical laboratory are compatible with
those obtained by other laboratories on the same specimen.
Serum protein electrophoresis is a laboratory test consisting
of five fractions (albumin, a1, a2, b and c globulins), which
sum up to 100% of total proteins. So far, in EQA schemes
the five fractions have been analyzed separately as for
ordinary tests like glucose or cholesterol. This approach
does not consider the fractions as a whole and the linear
relationship between them. A statistical approach has been
developed to analyze EQA electrophoresis results from a
global standpoint by using robust multivariate method to
eliminate the effect of outlying profiles. As illustrated on
electrophoretic data from the Belgian EQA scheme, the
novel approach improves the detection of poor performing
laboratories. The method will be implemented in the Belgian
EQA scheme on a routine basis.
http://hdl.handle.net/2268/11818
10.1007/s00769-008-0388-4

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