[en] The goal of External Quality Assessment (EQA)
schemes is to ensure that results obtained on a particular
specimen in a given clinical laboratory are compatible with
those obtained by other laboratories on the same specimen.
Serum protein electrophoresis is a laboratory test consisting
of five fractions (albumin, a1, a2, b and c globulins), which
sum up to 100% of total proteins. So far, in EQA schemes
the five fractions have been analyzed separately as for
ordinary tests like glucose or cholesterol. This approach
does not consider the fractions as a whole and the linear
relationship between them. A statistical approach has been
developed to analyze EQA electrophoresis results from a
global standpoint by using robust multivariate method to
eliminate the effect of outlying profiles. As illustrated on
electrophoretic data from the Belgian EQA scheme, the
novel approach improves the detection of poor performing
laboratories. The method will be implemented in the Belgian
EQA scheme on a routine basis.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Zhang, Lixin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Van Campenhout, Christel; Scientific Institute of Public Health > Department of Clinical Biology
Devleeschouwer, Nicole; Scientific Institute of Public Health > Department of Clinical Biology
Libeer, Jean-Claude; Scientific Institute of Public Health > Department of Clinical Biology
Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Language :
English
Title :
Statistical analysis of serum protein electrophoresis results in External Quality Assessment schemes
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