Asthme et tabac.

Adrenal Cortex Hormones/therapeutic use; Anti-Asthmatic Agents/therapeutic use; Asthma/drug therapy/physiopathology; Drug Resistance; Humans; Pulmonary Disease, Chronic Obstructive/drug therapy/physiopathology; Severity of Illness Index; Smoking/epidemiology/physiopathology

Abstract :

[en] Roughly 40% of asthmatics are or have been smokers. These smoking asthmatics have been largely overlooked in the past. Tobacco is today considered as a risk factor for asthma and it seems that smoking asthmatics exhibit a different phenotype as compared to non smoking asthmatics. The inflammatory substrate differs widely, not only with respect to the type of cells present in the airways, but also with respect to the mediators brought into play. On the clinical point of view the asthma of smokers is also more severe that in non smokers, both at the symptomatic and the functional level. The asthma severity in smokers is partly linked to a resistance to inhaled corticoids, the cornerstone of maintenance treatment in asthma. This makes urgent to assess alternative treatment to inhaled corticoids for this asthma phenotype, but also emphasizes the need to support smoking cessation in asthmatics.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Gusbin, N.

Garzaniti, N.

Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie

Language :

French

Title :

Asthme et tabac.

Alternative titles :

[en] Asthma and tabacco

Publication date :

2006

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

Issue :

Pages :

81-6

Peer reviewed :

Peer reviewed

Additional URL :

http://www.rmlg.ulg.ac.be/index.php?page=listeArt?date=2006%20Feb&langue=FR

Available on ORBi :

since 21 April 2009

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Scopus citations^®

Scopus citations^®
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Bibliography

Piipari R, Jaakola JJK, Jaakola N.- Smoking and asthma in adults. Eur Respir J, 2004, 24, 734-739.
Thomson NC, Chaudhuri R, Livingston E.- Asthma and cigarette smoking. Eur Respir J, 2004, 24, 822-833.
Haahtela T, Klaukka T, Koskela K et al.- Asthma programme in Finland: a community problem needs community solutions. Thorax, 2001, 56, 806-814.
Sandström T, Lundbäck B.- Tobacco smoke: old foe more important for asthma than commonly appreciated? Eur Respir J, 2004, 24, 720-721.
Fabbri LM, Romagnoli M, Corbetta L et al.- Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2003, 167, 418-424.
Louis R, Corhay JL, Bury T et al.- L'hyperréactivité bronchique non spécifique: Données épidémiologiques et signification clinique. Rev med de Liège, 1993, 58, 213-219.
Ramdsdale EH, Roberts RS, Morris MM et al.- Differences in responsiveness to hyperventilation and metacholine in asthma and chronic bronchitis. Thorax, 1985, 40, 422-426.
Oosterhoff Y, de Jong JW, Jansen MA et al.- Airway responsiveness to adenosine 5′-monophosphate in chronic obstructive pulmonary disease is determined by smoking. Am Rev Respir Dis, 1993, 147, 553-558.
Godtfredsen NS, Lange P, Prescott E et al.- Changes in smoking habits and risk of asthma: a longitudinal population based study. Eur Respir J, 2001, 18, 549-554.
Siroux V, Pin I, Oryszczyn MP et al.- Relationships of active smoking to asthma and asthma severity in the EGEA study. Eur Respir J, 2000, 15, 470-477.
James AL, Palmer LJ, Kicic E et al.- Decline in lung function in the Busselton Health Study. The effects of asthma and cigarette smoking. Am J Respir Crit Care Med, 2005, 111, 109-114.
Mitsunobu F, Ashida K, Hosaki Y et al.- Influence of long-term cigarette smoking on immunoglobulin E-mediated allergy, pulmonary function, and high-resolution computed tomography lung densitometry in elderly patients with asthma. Clin Exp Allergy, 2004, 34, 59-64.
Thomson NC, Chaudhuri R, Livingston E.- Active cigarette smoking and asthma. Clin Exp Allergy, 2003, 33, 1471-1475.
Willemse BWM, Postma DS, Timens W et al.- The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation. Eur Respir J, 2004, 23, 464-476.
McKay A, Komai-Koma M, MacLeod KJ, et al.- Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers. Clin Exp Allergy, 2004, 34, 904-910.
Keatings VM et al.- Differences in Interleukin-8 and Tumor Necrosis Factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med, 1996, 153, 530-534.
Chalmers GW, MacLeod KJ, Thomson L et al.- Smoking and airway inflammation in patients with mild asthma. Chest, 2001, 120, 1917-1922.
McCrea KA, Ensor JE, Nall K et al.- Altered cytokine regulation in the lungs of cigarette smokers. Am J Respir Crit Care Med, 1994, 150, 696-703.
Wooley KR et al.- Eosinophil apoptosis and the resolution of airway inflammation in asthma. Am J Respir Crit Care Med, 1996, 154, 237-243.
Barnes PJ, Adcock IM.- How do corticosteroids work in asthma? Ann Intern Med, 2003, 139, 359-370.
Barnes PJ, Ito K, Adcock IM.- Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. The Lancet, 2004, 363, 731-733.
Chalmers GW, MacLeod KJ, Little SA et al- Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax, 2002, 57, 226-230.
Chaudhuri R, Livingston E, McMahon AD et al.- Cigarette smoking impairs the therapeutic response to oral corticosteroid in chronic asthma. Am J Respir Crit Care Med, 2003, 168, 1308-1311.
Bel EH.- A neglected cause of glucocorticoid resistance in asthma. Am J Crit Care Med, 2003, 168, 1265-1266.
Tomlinson JEM, McMahon AD, Chaudhuri R et al.- Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma. Thorax, 2005, 60, 282-287.
Green RH, Brightling CE, Woltmann G et al.- Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax, 2002, 57, 875-879.
Webster JC, Oakley RH, Jewell CM et al.- Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance. PNAS, 2001, 98, 6865-6870.
Livingston E, Darroch CE, Chaudhuri R et al.- Glucocorticoid receptor α/β ratio in blood mononuclear cells is reduced in cigarette smokers. J Allergy Clin Immunol, 2004, 114, 1475-1478.
Ito K, Lim S, Caramori G et al.- A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. PNAS, 2002, 99, 8921-8926.
Jayaram L, Pizzichini E, Lemière C et al.- Steroid naive eosinophilic asthma: anti-inflammatory effects of fluticazone and montelukast. Thorax, 2005, 60, 100-105.
Simon HU, Seelbach H, Ehmann R et al.- Clinical and immunological effects of low-dose IFN-a treatment in patients with corticosteroid-resistant asthma. Allergy, 2003, 58, 1250-1255.