Reference : 2D DIGE, label free quantification, principal component and mass spectrometry analysi...
Scientific congresses and symposiums : Paper published in a journal
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/117739
2D DIGE, label free quantification, principal component and mass spectrometry analysis for biomarkers discovery in MCF-7/BOS cells exposed to 17β-estradiol and endocrine disruptors.
English
Collodoro, Mike mailto [Université de Liège - ULg > > > Doct. sc. (bioch., biol. mol.&cell., bioinf.&mod.-Bologne)]
Lemaire, Pascale [ > > ]
Eppe, Gauthier mailto [Université de Liège - ULg > > Chimie analytique inorganique >]
Bertrand, Virginie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Dobson, Rowan mailto [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
Mazzucchelli, Gabriel mailto [Université de Liège - ULg > > Center for Analytical Research and Technology (CART) >]
Widart, Joëlle mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
De Pauw, Edwin mailto [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
De Pauw-Gillet, Marie-Claire mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
2011
Organohalogen Compounds
Federal Environmental Agency
Yes (verified by ORBi)
No
International
1026-4892
Vienna
Austria
DIOXIN 2011
Aout 2011
[en] 17beta-estradiol ; MCF-7 BOS ; 2D DIGE ; Label free ; SRM ; xenoestrogens
[en] Endocrine system disruption has become a subject of great interest over the last few decades, since it has become
evident that natural and also synthetic substances can mimic or reduce the activity of endogenous hormones.
Compounds with estrogenic activity are an important family of potential endocrine disruptors that have to be
monitored either in the food chain or in the environment. Estrogens are known to induce or promote hormonal
dependent cancers, to reduce sperm counts and fertility in men and generate the feminization of exposed wildlife
populations.
The rapid screening of unwanted chemicals in the food chain is beset by difficulties. The number of toxic compounds
is very large and no universal method can cope with their diversity.
In this work, emergent differential proteomic techniques are used to discover a set of biomarkers for the development
of a multiple estrogen contaminants screening test.
GIGA-R
FRIA (FNRS)
http://hdl.handle.net/2268/117739

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