ORBi: Collodoro Mike - 2D DIGE, label free quantification, principal component and mass spectrometry analysis for biomarkers discovery in MCF-7/BOS cells exposed to 17β-estradiol and endocrine disruptors.

Reference : 2D DIGE, label free quantification, principal component and mass spectrometry analysis f...


	Document type :	Scientific congresses and symposiums : Paper published in a journal
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/117739

Title :	2D DIGE, label free quantification, principal component and mass spectrometry analysis for biomarkers discovery in MCF-7/BOS cells exposed to 17β-estradiol and endocrine disruptors.
Language :	English
Author, co-author :	Collodoro, Mike [Université de Liège - ULg > > > Doct. sc. (bioch., biol. mol.&cell., bioinf.&mod.-Bologne)]
	Lemaire, Pascale [ > > ]
	Eppe, Gauthier [Université de Liège - ULg > > Chimie analytique inorganique >]
	Bertrand, Virginie [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
	Dobson, Rowan [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
	Mazzucchelli, Gabriel [Université de Liège - ULg > > Center for Analytical Research and Technology (CART) >]
	Widart, Joëlle [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
	De Pauw, Edwin [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
	De Pauw-Gillet, Marie-Claire [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Publication date :	2011
Journal title :	Organohalogen Compounds
Publisher :	Federal Environmental Agency
Peer reviewed :	Yes (verified by ORBi)
On invitation :	No
Audience :	International
ISSN :	1026-4892
City :	Vienna
Country :	Austria
Event name :	DIOXIN 2011
Event date :	Aout 2011
Keywords :	[en] 17beta-estradiol ; MCF-7 BOS ; 2D DIGE ; Label free ; SRM ; xenoestrogens
Abstract :	[en] Endocrine system disruption has become a subject of great interest over the last few decades, since it has become evident that natural and also synthetic substances can mimic or reduce the activity of endogenous hormones. Compounds with estrogenic activity are an important family of potential endocrine disruptors that have to be monitored either in the food chain or in the environment. Estrogens are known to induce or promote hormonal dependent cancers, to reduce sperm counts and fertility in men and generate the feminization of exposed wildlife populations. The rapid screening of unwanted chemicals in the food chain is beset by difficulties. The number of toxic compounds is very large and no universal method can cope with their diversity. In this work, emergent differential proteomic techniques are used to discover a set of biomarkers for the development of a multiple estrogen contaminants screening test.
Research units :	GIGA-R
Funders :	FRIA (FNRS)
Permalink :	http://hdl.handle.net/2268/117739

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