Article (Scientific journals)
Acute and Specific Modulation of Presynaptic Aromatization in the Vertebrate Brain
Cornil, Charlotte; Leung, Cary H.; Pletcher, Eric R. et al.
2012In Endocrinology, 153 (6), p. 2562-7
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Abstract :
[en] Estrogens affect a diversity of peripheral and central physiological endpoints. Traditionally, estrogens were thought to be peripherally derived transcription regulators (i.e. slow acting). More recently, we have learned that estrogens are also synthesized in neuronal cell bodies and synaptic terminals and have potent membrane effects, which modulate brain function. However, the mechanisms that control local steroid concentrations in a temporal and spatial resolution compatible with their acute actions are poorly understood. Here, using differential centrifugation followed by enzymatic assay, we provide evidence that estrogen synthesis within synaptosomes can be modulated more dramatically by phosphorylating conditions, relative to microsomes. This is the first demonstration of a rapid mechanism that may alter steroid concentrations within the synapse and may represent a potential mechanism for the acute control of neurophysiology and behavior.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Cornil, Charlotte  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Leung, Cary H.
Pletcher, Eric R.
Naranjo, Kevin C.
Blauman, Sara J.
Saldanha, Colin J.
Language :
English
Title :
Acute and Specific Modulation of Presynaptic Aromatization in the Vertebrate Brain
Publication date :
2012
Journal title :
Endocrinology
ISSN :
0013-7227
eISSN :
1945-7170
Publisher :
Endocrine Society, Chevy Chase, United States - Maryland
Volume :
153
Issue :
6
Pages :
2562-7
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
NIH - National Institutes of Health [US-MD]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 23 April 2012

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