ORBi: Cornil Charlotte - Acute and Specific Modulation of Presynaptic Aromatization in the Vertebrate Brain

Reference : Acute and Specific Modulation of Presynaptic Aromatization in the Vertebrate Brain


	Document type :	Scientific journals : Article
	Discipline(s) :	Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/117376

Title :	Acute and Specific Modulation of Presynaptic Aromatization in the Vertebrate Brain
Language :	English
Author, co-author :	Cornil, Charlotte [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
	Leung, Cary H. [> >]
	Pletcher, Eric R. [> >]
	Naranjo, Kevin C. [> >]
	Blauman, Sara J. [> >]
	Saldanha, Colin J. [> >]
Publication date :	2012
Journal title :	Endocrinology
Publisher :	Endocrine Society
Volume :	153
Issue/season :	6
Pages :	2562-7
Audience :	International
ISSN :	0013-7227
City :	Chevy Chase
Country :	MD
Abstract :	[en] Estrogens affect a diversity of peripheral and central physiological endpoints. Traditionally, estrogens were thought to be peripherally derived transcription regulators (i.e. slow acting). More recently, we have learned that estrogens are also synthesized in neuronal cell bodies and synaptic terminals and have potent membrane effects, which modulate brain function. However, the mechanisms that control local steroid concentrations in a temporal and spatial resolution compatible with their acute actions are poorly understood. Here, using differential centrifugation followed by enzymatic assay, we provide evidence that estrogen synthesis within synaptosomes can be modulated more dramatically by phosphorylating conditions, relative to microsomes. This is the first demonstration of a rapid mechanism that may alter steroid concentrations within the synapse and may represent a potential mechanism for the acute control of neurophysiology and behavior.
Research units :	Giga-Neurosciences
Funders :	National Institutes of Health - NIH ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Permalink :	http://hdl.handle.net/2268/117376
DOI :	10.1210/en.2011-2159

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