ORBi: Detroz Bernard - Rationale for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the treatment or prevention of peritoneal carcinomatosis

Reference : Rationale for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the treatment or prev...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Surgery
	To cite this reference:	http://hdl.handle.net/2268/11705

Title :	Rationale for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the treatment or prevention of peritoneal carcinomatosis
Language :	English
Author, co-author :	Detroz, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	Laurent, Stanislas [> >]
	Honore, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	Blaffart, Francine [Centre Hospitalier Universitaire de Liège - CHU > > Bloc opératoire chirurgie cardio-vasculaire >]
	Limet, Raymond [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
	Meurisse, Michel [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Publication date :	2004
Journal title :	Acta Chirurgica Belgica
Publisher :	Acta Medica Belgica
Volume :	104
Pages :	377-384
ISSN :	0001-5458
City :	Bruxelles
Country :	Belgique
Keywords :	[en] Intraperitoneal chemotherapy ; hyperthermia ; peritoneal carcinomatosis
Abstract :	[en] Up to now, the prognosis of peritoneal carcinomatosis from GI tract cancers remains very poor. Intraperitoneal hyperthermic chemotherapy has been proposed in the prevention or treatment of peritoneal carcinomatosis. The rationale for this locoregional approach comes from a better knowledge of the physiopathology of the disease. Intraperitoneal chemotherapy achieves high local drug concentration with limited systemic toxicity. It should be performed during or immediately after surgery to be effective towards microscopic residual tumor cells. A synergistic cytotoxic effect has been demonstrated when heat is combined with antineoplastic drugs. Intraperitoneal hyperthermic chemotherapy might not be regarded as the panacée but as a promising step in the management of peritoneal carcinomatosis. Some randomized studies of gastric cancer with macroscopic serosal invasion have suggested the efficacy of hyperthermic intraperitoneal chemotherapy for the prevention of peritoneal carcinomatosis. In patients with peritoneal carcinomatosis, some studies suggest, in selected cases, the positive effect of hyperthermic intraperitoneal chemotherapy on survival, when combined with cytoreductive surgery.
Target :	Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/2268/11705

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