Reference : Rationale for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the treatment or prev...
Scientific journals : Article
Human health sciences : Surgery
http://hdl.handle.net/2268/11705
Rationale for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the treatment or prevention of peritoneal carcinomatosis
English
Detroz, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Laurent, Stanislas [> >]
Honore, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Blaffart, Francine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Bloc opératoire chirurgie cardio-vasculaire >]
Limet, Raymond mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Meurisse, Michel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
2004
Acta Chirurgica Belgica
Acta Medica Belgica
104
377-384
Yes (verified by ORBi)
0001-5458
Bruxelles
Belgique
[en] Intraperitoneal chemotherapy ; hyperthermia ; peritoneal carcinomatosis
[en] Up to now, the prognosis of peritoneal carcinomatosis from GI tract cancers remains very poor.
Intraperitoneal hyperthermic chemotherapy has been proposed in the prevention or treatment of peritoneal carcinomatosis.
The rationale for this locoregional approach comes from a better knowledge of the physiopathology of the disease.
Intraperitoneal chemotherapy achieves high local drug concentration with limited systemic toxicity. It should be
performed during or immediately after surgery to be effective towards microscopic residual tumor cells. A synergistic
cytotoxic effect has been demonstrated when heat is combined with antineoplastic drugs. Intraperitoneal hyperthermic
chemotherapy might not be regarded as the panacée but as a promising step in the management of peritoneal carcinomatosis.
Some randomized studies of gastric cancer with macroscopic serosal invasion have suggested the efficacy of hyperthermic
intraperitoneal chemotherapy for the prevention of peritoneal carcinomatosis. In patients with peritoneal carcinomatosis,
some studies suggest, in selected cases, the positive effect of hyperthermic intraperitoneal chemotherapy on
survival, when combined with cytoreductive surgery.
Professionals ; Students ; General public
http://hdl.handle.net/2268/11705

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