You are here:
| Reference : Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knock... |
| Scientific journals : Article | |||
| Human health sciences : Endocrinology, metabolism & nutrition Social & behavioral sciences, psychology : Neurosciences & behavior | |||
| http://hdl.handle.net/2268/11635 | |||
| Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knockout mice | |
| English | |
Bakker, Julie  [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >] | |
| Honda, S. [> > > >] | |
| Harada, N. [> > > >] | |
| Balthazart, Jacques [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >] | |
| Jun-2004 | |
| Hormones & Behavior | |
| Academic Press Inc Elsevier Science | |
| 46 | |
| 1 | |
| 1-10 | |
| Yes (verified by ORBi) | |
| International | |
| 0018-506X | |
| San Diego | |
| [en] sexual behavior ; aromatase knockout mice ; exogenous estrogens | |
| [en] We previously found that male aromatase knockout (ArKO) mice that carry a targeted mutation in exons 1 and 2 of the CYP 19 gene and as a result cannot aromatize androgen to estrogen show impaired sexual behavior in adulthood. To determine whether this impairment was due to a lack of activation of sexual behavior by estradiol, we studied here male coital behavior as well as olfactory investigation of sexually relevant odors in male ArKO mice following adult treatment with estradiol benzoate (EB) or dihydrotestosterone propionate (DHTP). Again, we found that gonadally intact ArKO males show pronounced behavioral deficits affecting their male coital behavior as well as their olfactory investigation of volatile body odors but not that of soiled bedding. Deficits in male coital behavior were largely corrected following adult treatment with EB and the androgen DHTP, suggesting that estradiol has prominent activational effects on this behavior. By contrast, adult treatment with EB to either castrated or gonadally intact ArKO males did not stimulate olfactory investigation of volatile body odors, suggesting that this impairment may result from a lack of proper organization of this behavior during ontogeny due to the chronic lack of estrogens. In conclusion, the present studies suggest that the behavioral deficits in sexual behavior in male ArKO mice result predominantly from a lack of activation of the behavior by estrogens. This is in contrast with earlier pharmacological studies performed on rats and ferrets that have suggested strong organizational effects of estradiol on male sexual behavior. (C) 2004 Elsevier Inc. All rights reserved. | |
| http://hdl.handle.net/2268/11635 | |
| 10.1016/j.yhbeh.2004.02.003 |
| File(s) associated to this reference | ||||||||||||||
|
Fulltext file(s):
| ||||||||||||||
All documents in ORBi are protected by a user license.
