Reference : Role of glucosamine in the treatment for osteoarthritis.
Scientific journals : Article
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/116309
Role of glucosamine in the treatment for osteoarthritis.
English
REGINSTER, Jean-Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur]
Neuprez, Audrey [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé]
LECART, Marie-Paule mailto [Centre Hospitalier Universitaire de Liège - CHU > > Algologie - soins palliatifs >]
SARLET, Nathalie [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur]
Bruyère, Olivier mailto [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé]
Oct-2012
Rheumatology International
Springer Science & Business Media B.V.
32
10
2959-67
Yes (verified by ORBi)
International
0172-8172
New York
NY
[en] Glucosamine ; Osteoarthritis ; Treatment ; Symptoms ; Structure
[en] Over the last 20 years, several studies have investigated the ability of glucosamine sulfate to improve the symptoms (pain and function) and to delay the structural progression of osteoarthritis. There is now a large, convergent body of evidence that glucosamine sulfate, given at a daily oral dose of 1,500 mg, is able to significantly reduce the symptoms of osteoarthritis in the lower limbs. This dose of glucosamine sulfate has also been shown, in two independent studies, to prevent the joint space narrowing observed at the femorotibial compartment in patients with mild-to-moderate knee osteoarthritis. This effect also translated into a 50 % reduction in the incidence of osteoarthritis-related surgery of the lower limbs during a 5-year period following the withdrawal of the treatment. Some discrepancies have been described between the results of studies performed with a patent-protected formulation of glucosamine sulfate distributed as a drug and those having used glucosamine preparations purchased from global suppliers, packaged, and sold over-the-counter as nutritional supplements.
http://hdl.handle.net/2268/116309
10.1007/s00296-012-2416-2

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