ORBi: Detry Olivier - Transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured in a non-heart beating donor

Reference : Transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Gastroenterology & hepatology Human health sciences : Oncology Human health sciences : Surgery
	To cite this reference:	http://hdl.handle.net/2268/1162

Title :	Transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured in a non-heart beating donor
Language :	English
Author, co-author :	Detry, Olivier [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	De Roover, Arnaud [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	de Leval, Laurence [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
	Herens, Christian [Centre Hospitalier Universitaire de Liège - CHU > > PLAN COS >]
	Delwaide, Jean [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
	Honore, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	Meurisse, Michel [Université de Liège - ULg > Département des sciences cliniques > Chirurgicale abdominale]
Publication date :	Jun-2005
Journal title :	Liver Transplantation
Publisher :	John Wiley & Sons Inc
Volume :	11
Issue/season :	6
Pages :	696-699
Audience :	International
ISSN :	1527-6465
City :	Hoboken
Keywords :	[en] cancer ; transplantation ; transmission ; liver transplantation ; complication
Abstract :	[en] Transmission of an undiagnosed cancer with solid organ transplantation is a rare but dreadful event. In this paper the authors report the transmission of an undiagnosed sarcoma to recipients of kidney and liver grafts procured in a Maastricht category 3 non-heart beating donor. To the authors' knowledge this case is the first report of such a transmission with a liver graft procured in a non-heart beating donor. The cancer transferal was diagnosed I year after transplantation in the recipients of the liver and of one kidney. The liver recipient died from multiple organ failure after a failed attempt of tumor resection. The kidney recipient underwent immunosuppression withdrawal and transplantectomy. Non-heart beating donors should not be particularly at risk for undiagnosed cancer transmission if the procurement is performed according to the same rules of careful inspection of the abdominal and thoracic organs. After diagnosis of donor cancer transmission, kidney recipients should have the graft removed, and immunosuppression should be interrupted. The management of liver graft recipients is very difficult in this setting, and long-term survival was very rarely reported.
Target :	Professionals ; Students
Permalink :	http://hdl.handle.net/2268/1162

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