Initial adherence of EPEC, EHEC and VTEC to host cells.

Animals; Bacterial Adhesion/physiology; Enterohemorrhagic Escherichia coli/physiology; Enteropathogenic Escherichia coli/physiology; Intestines/cytology; Shiga-Toxigenic Escherichia coli/physiology

Abstract :

[en] Initial adherence to host cells is the first step of the infection of enteropathogenic Escherichia coli (EPEC), enterohaemorrhagic Escherichia coli (EHEC) and verotoxigenic Escherichia coli (VTEC) strains. The importance of this step in the infection resides in the fact that (1) adherence is the first contact between bacteria and intestinal cells without which the other steps cannot occur and (2) adherence is the basis of host specificity for a lot of pathogens. This review describes the initial adhesins of the EPEC, EHEC and VTEC strains. During the last few years, several new adhesins and putative colonisation factors have been described, especially in EHEC strains. Only a few adhesins (BfpA, AF/R1, AF/R2, Ral, F18 adhesins) appear to be host and pathotype specific. The others are found in more than one species and/or pathotype (EPEC, EHEC, VTEC). Initial adherence of EPEC, EHEC and VTEC strains to host cells is probably mediated by multiple mechanisms.

Disciplines :

Veterinary medicine & animal health
Microbiology

Author, co-author :

Bardiau, Marjorie ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Bactériologie et pathologie des maladies bactériennes

Szalo, Ioan Mihai ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Médecine des oiseaux, des lagomorphes et des rongeurs

Mainil, Jacques ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Bactériologie et pathologie des maladies bactériennes

Language :

English

Title :

Initial adherence of EPEC, EHEC and VTEC to host cells.

Publication date :

2010

Journal title :

Veterinary Research

ISSN :

0928-4249

eISSN :

1297-9716

Publisher :

EDP Sciences, Les Ulis, France

Volume :

Issue :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 04 April 2012

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