Article (Scientific journals)
A review of gliptins in 2011.
SCHEEN, André
2012In Expert Opinion on Pharmacotherapy, 13 (1), p. 81-99
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Keywords :
Clinical trial; DPP-4 inhibitor; Gliptin; Pharmacodynamics; Pharmacokinetics; Type 2 diabetes mellitus
Abstract :
[en] INTRODUCTION: Dipeptidylpeptidase-4 (DPP-4) inhibitors offer new options for the management of type 2 diabetes (T2DM). AREAS COVERED: This paper is an updated review, providing an analysis of both the similarities and the differences between the various compounds known as gliptins, currently used in the clinic (sitagliptin, vildagliptin, saxagliptin, alogliptin and linagliptin). This paper discusses the pharmacokinetic and pharmacodynamic characteristics of gliptins; both the efficacy and safety profiles of gliptins in clinical trials (compared with classical glucose-lowering agents), given as monotherapy or in combination, including in special populations; the positioning of DPP-4 inhibitors in the management of T2DM in recent guidelines; and various unanswered questions and perspectives. EXPERT OPINION: The role of DPP-4 inhibitors in the therapeutic armamentarium of T2DM is evolving, as their potential strengths and weaknesses become better defined. Future critical issues may include the durability of glucose control, resulting from better beta-cell protection, positive effects on cardiovascular outcomes and long-term safety issues.
Disciplines :
Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition
Author, co-author :
SCHEEN, André  ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Language :
English
Title :
A review of gliptins in 2011.
Publication date :
2012
Journal title :
Expert Opinion on Pharmacotherapy
ISSN :
1465-6566
eISSN :
1744-7666
Publisher :
Ashley Publications Ltd, London, United Kingdom
Volume :
13
Issue :
1
Pages :
81-99
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 April 2012

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