Article (Scientific journals)
Does cognitive impairment influence burden in caregivers of patients with Alzheimer’s disease?
Germain, Sophie; Adam, Stéphane; Olivier, Catherine et al.
2009In Journal of Alzheimer's Disease, 17 (1), p. 105-114
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Keywords :
Alzheimer; burden; Caregivers; cognitive impairment; behavioral symptoms; activities of daily living
Abstract :
[en] Alzheimer's disease is characterized by a progressive deterioration of various cognitive and behavioral abilities and it also has a health impact on the patients’ caregiver. Our aim was to determine the patient (and to a lesser extent the caregiver’s) characteristics that contribute most to the caregiver burden. We used the baseline data from the ICTUS study, a European longitudinal cohort of patients with mild to moderate AD. Data from 1091 patients and their caregivers has been used for analysis. Three principal components analyses were performed on variables from the domains of cognition, neuropsychiatric symptoms and daily function using MMSE plus ADAS-Cog, NPI and IADL subscores respectively. These were followed by a stepwise logistic regression to identify patient characteristics which best predict caregiver burden. The regression model (R2 = 0.35, p < .001) shows that the best explanatory variables are (1) neuropsychiatric symptoms (NPI), (2) difficulties in the IADL, (3) time taken by caregiving, (4) demographic variables such as caregiver’s age and patient sex and (5) severity of cognitive impairment. In conclusion, our results demonstrate that although the strongest determinant of the caregiver burden is behavioral disturbance, the impact of the degree of cognitive impairment on burden is also significant.
Research center :
Centre de la Mémoire CHU de Liège
Disciplines :
Neurosciences & behavior
Author, co-author :
Germain, Sophie ;  Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Adam, Stéphane  ;  Université de Liège - ULiège > Services généraux (Fac. de psycho. et des sc. de l'éducat.) > Service administratif de la Fac. (Psycho et sc. éducation)
Olivier, Catherine ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Cash, Helen
Ousset, Pierre Jean
Andrieu, Sandrine
Vellas, Bruno
Meulemans, Thierry ;  Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Reynish, Emma
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Does cognitive impairment influence burden in caregivers of patients with Alzheimer’s disease?
Publication date :
2009
Journal title :
Journal of Alzheimer's Disease
ISSN :
1387-2877
eISSN :
1875-8908
Publisher :
IOS Press
Volume :
17
Issue :
1
Pages :
105-114
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
EADC - European Alzheimer's Disease Consortium [BE]
Available on ORBi :
since 20 April 2009

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