Article (Scientific journals)
Glitazones et insuffisance cardiaque: resultats des etudes PROactive, ADOPT, DREAM et RECORD.
De Flines, Jenny; Scheen, André
2007In Revue Médicale Suisse, 3 (122), p. 1876, 1878-83
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Keywords :
Clinical Trials as Topic; Diabetes Mellitus, Type 2/drug therapy; Heart Failure/chemically induced; Humans; Hypoglycemic Agents/administration & dosage/adverse effects; Thiazolidinediones/administration & dosage/adverse effects
Abstract :
[en] Thiazolidinediones (TZDs) are used as insulin sensitizers in the treatment of type 2 diabetes, but are associated with an increased risk of congestive heart failure (CHF). The odds ratio of ICC was 1.43 (pioglitazone vs placebo) in diabetic patients with high cardiovascular risk in the PROactive trial while it averaged 1.22 (rosiglitazone vs metformin) and 2.20 (rosiglitazone vs metformin) in the ADOPT study. In the interim analysis of the ongoing RECORD trial, the odds ratio averaged 2.15 (rosiglitazone vs metformin or sulfonylureas). In four real life registries, the relative risk of CHF with TZDs varied between 1.06 and 1.76 (between 1.10 and 1.44 combined with insulin) as compared to a treatment without TZDs. Such higher CHF risk should be appreciated according to the potential benefits of glitazones in the management of type 2 diabetes.
Disciplines :
Pharmacy, pharmacology & toxicology
Cardiovascular & respiratory systems
Endocrinology, metabolism & nutrition
Author, co-author :
De Flines, Jenny ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Glitazones et insuffisance cardiaque: resultats des etudes PROactive, ADOPT, DREAM et RECORD.
Alternative titles :
[en] Glitazones and congestive heart failure: update on PROactive, ADOPT, DREAM and RECORD clinical trials
Publication date :
2007
Journal title :
Revue Médicale Suisse
ISSN :
1660-9379
Publisher :
Medecine et Hygiène, Switzerland
Volume :
3
Issue :
122
Pages :
1876, 1878-83
Peer reviewed :
Peer Reviewed verified by ORBi
Additional URL :
Available on ORBi :
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