Article (Scientific journals)
Hearing Preservation in Cochlear Implantation and Drug Treatment.
Barriat, Sébastien; Poirrier, Anne-Lise; Malgrange, Brigitte et al.
2010In Advances in Oto-Rhino-Laryngology, 67, p. 6-13
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Abstract :
[en] Insertion of an electrode array into the cochlea produces immediate damage to the inner ear, which is responsible for a hearing loss. In addition, a delayed hearing loss can be observed. In order to maximize hearing preservation after insertion of an electrode and to enhance the performance of the cochlear implant, it has been proposed to deliver pharmacological agents to the inner ear. Molecules can be administered locally to the inner ear through a direct perilymphatic perfusion or through the round window membrane. These modalities of treatment have already been successfully applied to some patients with inner ear diseases. In this paper, we will review some basic aspects of drug delivery to the inner ear to prevent the degeneration of the neurosensory hair cells and auditory neurons, and the actual applicability to humans in order to maintain hearing function after the insertion of electrodes of a cochlear implant.
Disciplines :
Otolaryngology
Neurology
Author, co-author :
Barriat, Sébastien ;  Centre Hospitalier Universitaire de Liège - CHU > O.R.L.
Poirrier, Anne-Lise  ;  Centre Hospitalier Universitaire de Liège - CHU > O.R.L.
Malgrange, Brigitte  ;  Université de Liège - ULiège > GIGA - Neurosciences - Neurologie
Lefèbvre, Philippe ;  Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie
Language :
English
Title :
Hearing Preservation in Cochlear Implantation and Drug Treatment.
Publication date :
2010
Journal title :
Advances in Oto-Rhino-Laryngology
ISSN :
0065-3071
Publisher :
Karger, Basel, Switzerland
Volume :
67
Pages :
6-13
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2010 S. Karger AG, Basel.
Available on ORBi :
since 29 January 2010

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