Reference : Annexins as organizers of cholesterol- and sphingomyelin-enriched membrane microdomains ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/114573
Annexins as organizers of cholesterol- and sphingomyelin-enriched membrane microdomains in Niemann-Pick type C disease.
English
Domon, Magdalena [> >]
Nasir, Mehmet Nail mailto [Université de Liège - ULg > Chimie et bio-industries > Chimie biologique industrielle >]
Matar, Gladys [> >]
Pikula, Slawomir [> >]
Besson, Françoise [> >]
Bandorowicz-Pikula, Joanna [> >]
2011
Cellular and Molecular Life Sciences : CMLS
Birkhäuser
69
11
1773-1785
Yes (verified by ORBi)
International
1420-682X
1420-9071
Basel
Switzerland
[en] Growing evidence suggests that membrane microdomains enriched in cholesterol and sphingomyelin are sites for numerous cellular processes, including signaling, vesicular transport, interaction with pathogens, and viral infection, etc. Recently some members of the annexin family of conserved calcium and membrane-binding proteins have been recognized as cholesterol-interacting molecules and suggested to play a role in the formation, stabilization, and dynamics of membrane microdomains to affect membrane lateral organization and to attract other proteins and signaling molecules onto their territory. Furthermore, annexins were implicated in the interactions between cytosolic and membrane molecules, in the turnover and storage of cholesterol and in various signaling pathways. In this review, we focus on the mechanisms of interaction of annexins with lipid microdomains and the role of annexins in membrane microdomains dynamics including possible participation of the domain-associated forms of annexins in the etiology of human lysosomal storage disease called Niemann-Pick type C disease, related to the abnormal storage of cholesterol in the lysosome-like intracellular compartment. The involvement of annexins and cholesterol/sphingomyelin-enriched membrane microdomains in other pathologies including cardiac dysfunctions, neurodegenerative diseases, obesity, diabetes mellitus, and cancer is likely, but is not supported by substantial experimental observations, and therefore awaits further clarification.
http://hdl.handle.net/2268/114573
10.1007/s00018-011-0894-0
http://www.springerlink.com/content/25248t064m024447/

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