ORBi: PHAN BA Remy - Motor fatigue measurement by distance-induced slow down of walking speed in multiple sclerosis

Reference : Motor fatigue measurement by distance-induced slow down of walking speed in multiple scl...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Neurology
	To cite this reference:	http://hdl.handle.net/2268/114519

Title :	Motor fatigue measurement by distance-induced slow down of walking speed in multiple sclerosis
Language :	English
Author, co-author :	PHAN BA, Remy [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
	CALAY, Philippe [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
	GRODENT, Patrick [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur >]
	DELRUE, Gaël [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
	LOMMERS, Emilie [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
	DELVAUX, Valérie [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
	Moonen, Gustave [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
	Belachew, Shibeshih [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Publication date :	Apr-2012
Journal title :	PLoS ONE
Publisher :	Public Library of Science
Volume :	7
Issue/season :	4
Pages :	e34744
Audience :	International
e-ISSN :	1932-6203
City :	San Franscisco
Country :	CA
Keywords :	[en] Multiple Sclerosis ; Ambulation ; Walking speed ; Motor fatigue ; Outcome measures ; Gait
Abstract :	[en] Background: Motor fatigue and ambulation impairment are prominent clinical features of people with multiple sclerosis (pMS). We hypothesized that a multimodal and comparative assessment of walking speed on short and long distance would allow a better delineation and quantification of gait fatigability in pMS. Objectives: To compare 4 walking paradigms: the timed 25-foot walk (T25FW), a corrected version of the T25FW with dynamic start (T25FW+), the timed 100-meter walk (T100MW) and the timed 500-meter walk (T500MW). Methods: Thirty controls and 81 pMS performed the 4 walking tests in a single study visit. Results: The 4 walking tests were performed with a slower WS in pMS compared to controls even in subgroups with minimal disability. The finishing speed of the last 100-meter of the T500MW was the slowest measurable WS whereas the T25FW+ provided the fastest measurable WS. The ratio between such slowest and fastest WS (Deceleration Index, DI) was significantly lower only in pMS with EDSS 4.0-6.0, a pyramidal or cerebellar functional system score reaching 3 or a maximum reported walking distance !4000m. Conclusion: The motor fatigue which triggers gait deceleration over a sustained effort in pMS can be measured by the WS ratio between performances on a very short distance and the finishing pace on a longer more demanding task. The absolute walking speed is abnormal early in MS whatever the distance of effort when patients are unaware of ambulation impairment. In contrast, the DI-measured ambulation fatigability appears to take place later in the disease course.
Permalink :	http://hdl.handle.net/2268/114519
DOI :	10.1371/journal.pone.0034744
Other URL :	http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0034744

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Open access	journal.pone.0034744.pdf		Publisher postprint	387.39 kB	View/Open

All documents in ORBi are protected by a user license.

Dspace v1.5