ORBi: Rambout Xavier - Establishment of an interactomic map of the Ets factors family: Towards a better understanding of their roles in oncogenic processes

Reference : Establishment of an interactomic map of the Ets factors family: Towards a better underst...


	Document type :	Scientific congresses and symposiums : Poster
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/114163

Title :	Establishment of an interactomic map of the Ets factors family: Towards a better understanding of their roles in oncogenic processes
Language :	English
Author, co-author :	Rambout, Xavier [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
	Twizere, Jean-Claude [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
	Dequiedt, Franck [Université de Liège - ULg > > GIGA-Research >]
Publication date :	Mar-2010
Page number :	A1
On invitation :	No
Audience :	International
Event name :	Interactomics: at the crossroads of biology and bioinformatics
Event date :	du 30 mars 2010 au 1er avril 2010
Event organizer :	Brun, Christine
Event place (city) :	Saint-Raphaël
Event country :	France
Abstract :	[en] Ets transcription factors play key roles in several cancers such as leukemia, prostate cancer and Ewing’s sarcoma. They regulate the expression of genes controlling biological processes such as cellular proliferation, differentiation, apoptosis, metastasis, and transformation. This family is characterized by a highly conserved DNA-binding domain (ETS domain) and is classified into subfamilies according to sequence homology between the members. Using a high-throughput yeast two-hybrid (Y2H) method, we tested the interaction of the major splicing variants of the 28 human Ets factors and their functional domains of interest against the last available version of the human ORFeome (hORFeome v5.1). This screen has identified more than 200 new partners of Ets proteins. Further validation of these new interactions together with previously described interactions will enable a global evaluation of the regulation, and normal and cancerous roles of Ets factors.
Research units :	Giga-Signal Transduction
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Télévie ; Fondation contre le Cancer
Name of the research project :	Establishment of an interactomic map of the Ets factors family: Towards a better understanding of their roles in oncogenic processes
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/114163

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Restricted access	Poster St-Raphael_Xavier Rambout.pdf		Author preprint	1.44 MB	Request copy

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