Reference : Establishment of an interactomic map of the Ets factors family: Towards a better unde...
Scientific congresses and symposiums : Paper published in a book
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/114163
Establishment of an interactomic map of the Ets factors family: Towards a better understanding of their roles in oncogenic processes
English
Rambout, Xavier mailto [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
Twizere, Jean-Claude mailto [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
Dequiedt, Franck mailto [Université de Liège - ULg > > GIGA-Research >]
Mar-2010
Inserm Workshop: Interactomics: at the crossroads of biology and bioinformatics
Yes
No
International
Interactomics: at the crossroads of biology and bioinformatics
du 30 mars 2010 au 1er avril 2010
Brun, Christine
Saint-Raphaël
France
[en] Ets transcription factors play key roles in several cancers such as leukemia, prostate cancer and Ewing’s sarcoma.
They regulate the expression of genes controlling biological processes such as cellular proliferation, differentiation,
apoptosis, metastasis, and transformation. This family is characterized by a highly conserved DNA-binding domain (ETS
domain) and is classified into subfamilies according to sequence homology between the members.
Using a high-throughput yeast two-hybrid (Y2H) method, we tested the interaction of the major splicing variants of the
28 human Ets factors and their functional domains of interest against the last available version of the human
ORFeome (hORFeome v5.1). This screen has identified more than 200 new partners of Ets proteins.
Further validation of these new interactions together with previously described interactions will enable a global
evaluation of the regulation, and normal and cancerous roles of Ets factors.
Giga-Signal Transduction
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Télévie ; Fondation contre le Cancer
Establishment of an interactomic map of the Ets factors family: Towards a better understanding of their roles in oncogenic processes
Researchers
http://hdl.handle.net/2268/114163
http://www.nbic.nl/research/events/detail/article/interactomics-at-the-crossroads-of-biology-and-bioinformatics/

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