|Reference : Role of the Cholinergic Pathway in Mediating Platelet-Activating Factor-Induced Pulmonar...|
|Scientific journals : Article|
|Life sciences : Veterinary medicine & animal health|
|Role of the Cholinergic Pathway in Mediating Platelet-Activating Factor-Induced Pulmonary Dysfunctions in Unsedated Calves|
|Van de Weerdt, Marie Lyse [> > > >]|
|Husson, Cécile [> > > >]|
|Lekeux, Pierre [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]|
|Zentralblatt fur Veterinarmedizin. Reihe A|
|[en] Pulmonary dysfunctions ; calves|
|[en] The purpose of this study was to investigate the possible role of the cholinergic pathway in mediating platelet-activating factor (PAF)-induced pulmonary dysfunctions in unsedated calves. In a placebo group, PAF infusion challenge induced significant dysfunctions in the pattern of breathing [a significant increase in respiratory rate (RR) and a significant decrease in tidal volume (VT)], the mechanics of breathing [a significant increase in total lung resistance (RL) and a significant decrease in dynamic lung compliance (CLdyn)] and gas exchange, whereas in atropine pre-treated calves, PAF infusion challenge induced a significant increase in RR, VT and HR and a significant decrease in CLdyn. The RL increase was prevented by atropine pre-treatment. On the basis of our findings, we suggest that, in cattle, the PAF-induced pattern of breathing dysfunctions and the diffuse bronchoconstriction and microvascular leakage of small airways are not mediated through the cholinergic pathway. By contrast, our data suggest that PAF-induced bronchoconstriction of upper airways is at least partly mediated through muscarinic receptors.|
|Researchers ; Professionals|
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