Reference : Gesture Subtype-Dependent Left Lateralization of Praxis Planning: An Event-Related fMRI ...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/11364
Gesture Subtype-Dependent Left Lateralization of Praxis Planning: An Event-Related fMRI Study.
English
Bohlhalter, Stephan [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Hattori, Nori [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Wheaton, Lewis [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Fridman, Esteban [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Shamim, E. A. [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Garraux, Gaëtan mailto [Université de Liège - ULg & Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > >]
Hallett, Mark [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
2008
Cerebral Cortex
Oxford University Press
Yes (verified by ORBi)
International
1047-3211
1460-2199
Cary
NC
[en] Ideomotor apraxia is a disorder mainly of praxis planning, and the deficit is typically more evident in pantomiming transitive (tool related) than intransitive (communicative) gestures. The goal of the present study was to assess differential hemispheric lateralization of praxis production using event-related functional magnetic resonance imaging. Voxel-based analysis demonstrated significant activations in posterior parietal cortex (PPC) and premotor cortex (PMC) association areas, which were predominantly left hemispheric, regardless of whether planning occurred for right or left hand transitive or intransitive pantomimes. Furthermore, region of interest-based calculation of mean laterality index (LI) revealed a significantly stronger left lateralization in PPC/PMC clusters for planning intransitive (LI = -0.49 + 0.10, mean + standard deviation [SD]) than transitive gestures (-0.37 + 0.08, P = 0.02, paired t-tests) irrespective of the hand involved. This differential left lateralization for planning remained significant in PMC (LI = -0.47 + 0.14 and -0.36 + 0.13, mean + SD, P = 0.04), but not in PPC (-0.56 + 0.11 and -0.45 + 0.12, P = 0.11), when both regions were analyzed separately. In conclusion, the findings point to a left-hemispheric specialization for praxis planning, being more pronounced for intransitive gestures in PMC, possibly due to their communicative nature.
NINDS - National Institutes of Health - NIH - USA
Researchers ; Professionals
http://hdl.handle.net/2268/11364
10.1093/cercor/bhn168
http://cercor.oxfordjournals.org/cgi/content/abstract/bhn168v1

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Bohlhalter praxis fMRI 2008.pdfNo commentaryPublisher postprint634.63 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.