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| Reference : Neural correlates of tic generation in Tourette syndrome: an event-related functional MR... |
| Scientific journals : Article | |||
| Human health sciences : Radiology, nuclear medicine & imaging Human health sciences : Neurology | |||
| http://hdl.handle.net/2268/11358 | |||
| Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study. | |
| English | |
| Bohlhalter, Stephan [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >] | |
| Goldfine, Andrew [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >] | |
| Matteson, S. [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >] | |
Garraux, Gaëtan  [Université de Liège - ULg & Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > >] | |
| Hanakawa, Takashi [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >] | |
| Kansaku, Kenji [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >] | |
| Wurzman, Rachel [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >] | |
| Hallett, Mark [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >] | |
| 2006 | |
| Brain : A Journal of Neurology | |
| Oxford University Press | |
| 129 | |
| Pt 8 | |
| 2029-37 | |
| International | |
| 0006-8950 | |
| 1460-2156 | |
| Oxford | |
| United Kingdom | |
| [en] Adult ; Blinking ; Brain/physiopathology ; Brain Mapping/methods ; Female ; Humans ; Image Processing, Computer-Assisted ; Limbic System/physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Activity ; Tourette Syndrome/physiopathology | |
| [en] Little is known about the neural correlates of tics and associated urges. In the present study, we aimed to explore the neural basis of tics in patients with Tourette syndrome by using event-related functional MRI (fMRI). Ten patients (6 women, 4 men; age: mean +/- SD = 31 +/- 11.2) were studied while spontaneously exhibiting a variety of motor and vocal tics. On the basis of synchronized video/audio recordings, fMRI activities were analysed 2 s before and at tic onset irrespective of the clinical phenomenology. We identified a brain network of paralimbic areas such as anterior cingulate and insular cortex, supplementary motor area (SMA) and parietal operculum (PO) predominantly activated before tic onset (P < 0.05, corrected for multiple comparisons). In contrast, at the beginning of tic action, significant fMRI activities were found in sensorimotor areas including superior parietal lobule bilaterally and cerebellum. The results of this study indicate that paralimbic and sensory association areas are critically implicated in tic generation, similar to movements triggered internally by unpleasant sensations, as has been shown for pain or itching. | |
| NINDS - National Institutes of Health - NIH - USA | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/11358 | |
| 10.1093/brain/awl050 | |
| http://brain.oxfordjournals.org/cgi/content/full/129/8/2029 |
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