ORBi: Devy L. - Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Reference : Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and A...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Laboratory medicine & medical technology
	To cite this reference:	http://hdl.handle.net/2268/113567

Title :	Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis
Language :	English
Author, co-author :	Devy, L. [> > > >]
	Huang, L. [> > > >]
	Naa, L. [> > > >]
	Yanamandra, N. [> > > >]
	Pieters, H. [> > > >]
	Frans, N. [> > > >]
	Chang, E. [> > > >]
	Tao, Q. [> > > >]
	Vanhove, M. [ > > ]
	Lejeune, Annabelle [Université de Liège - ULg > > > >]
	van Gool, R. [> > > >]
	Sexton, D. J. [> > > >]
	Kuang, G. [> > > >]
	Rank, D. [> > > >]
	Hogan, S. [> > > >]
	Pazmany, C. [> > > >]
	Ma, Y. L. [> > > >]
	Schoonbroodt, S. [> > > >]
	Nixon, A. E. [> > > >]
	Ladner, R. C. [> > > >]
	Hoet, R. [> > > >]
	Henderikx, P. [> > > >]
	TenHoor, C. [> > > >]
	Rabbani, S. A. [> > > >]
	Valentino, M. L. [> > > >]
	Wood, C. R. [> > > >]
	Dransfield, D. T. [ > > ]
Publication date :	2009
Journal title :	Cancer Research
Publisher :	American Association for Cancer Research, Inc. (AACR)
Volume :	69
Issue/season :	4
Pages :	1517-1526
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0008-5472
e-ISSN :	1538-7445
City :	Baltimore
Country :	MD
Abstract :	[en] Inhibition of specific matrix metalloproteinases (MNIP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization. Besides cleaving matrix proteins, MMP-14 activates proMMP-2 leading to an amplification of pericellular proteolytic activity. To examine the contribution of MMP-14 to tumor growth and angiogenesis, we used DX-2400, a highly selective fully human MMP-14 inhibitory antibody discovered using phage display technology. DX-2400 blocked proMMP-2 processing on tumor and endothelial cells, inhibited angiogenesis, and slowed tumor progression and formation of metastatic lesions. The combination of potency, selectivity, and robust in vivo activity shows the potential of a selective MMP-14 inhibitor for the treatment of solid tumors. [Cancer Res 2009;69(4):1517-26]
Permalink :	http://hdl.handle.net/2268/113567
DOI :	10.1158/0008-5472.can-08-3255

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