Reference : Increased midbrain gray matter in Tourette's syndrome
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Human health sciences : Neurology
http://hdl.handle.net/2268/11354
Increased midbrain gray matter in Tourette's syndrome
English
Garraux, Gaëtan mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > > >]
Goldfine, Andrew [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Bohlhalter, Stephan [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Lerner, Alicia [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Hanakawa, Takashi [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Hallett, Mark [Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA > > > > > >]
Feb-2006
Annals of Neurology
Wiley Liss, Inc.
59
2
381-385
Yes (verified by ORBi)
International
0364-5134
Hoboken
[en] Tourette syndrome ; MRI ; gray matter
[en] Objective: To investigate cerebral structure in Tourette's syndrome (TS). Methods: Voxel-based morphometry study of high-resolution MRIs in 31 TS patients compared with 31 controls. Results: Increased gray matter mainly in the left mesencephalon in 31 TS patients. Interpretation: This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508514) according to which midbrain disturbances play an important pathogenic role in TS.
NINDS - National Institutes of Health - NIH - USA ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fondation Horlait-Dapsens (University of Liège). ; Fondation Léon Frédéricq (University of Liège). ; Belgian American Educational Foundation - BAEF
Researchers ; Professionals
http://hdl.handle.net/2268/11354
10.1002/ana.20765
http://www3.interscience.wiley.com/journal/112345233/abstract

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