Reference : Cerebral metabolic correlates of four dementia scales in Alzheimer's disease
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Human health sciences : Neurology
http://hdl.handle.net/2268/11346
Cerebral metabolic correlates of four dementia scales in Alzheimer's disease
English
Salmon, Eric mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > >]
Lespagnard, Solange [Université de Liège - ULG > Département des sciences cognitives > Neuropsychologie > >]
Marique, Patricia [Université de Liège - ULG > Departement des Sciences cognitives > Neuropsychologie > >]
Peeters [Université de Liège - ULG > Departement des Sciences cognitives > Neuropsychologie > >]
Herholz, Karl [Department of Neurology & Max-Planck Institute for Neurological Research, University Cologne, Cologne > > > > > >]
Perani, Daniela [Vita Salute San Raffaele University, Via Olgenttina 60, 20132 Milan, Italy > > > > > >]
Holthoff, Vera [Department of Psychiatry and Psychotherapy, Dresden University of Technology, Fletscherstr 74, 01307 Dresden, Germany > > > > > >]
Kalbe, E. [Department of Neurology & Max-Planck Institute for Neurological Research, University Cologne, Cologne > > > > > >]
Anchisi, D. [Vita Salute San Raffaele University, Via Olgenttina 60, 20132 Milan, Italy > > > > > >]
Adam, Stéphane mailto [Université de Liège - ULg > Département des sciences cognitives > Département des sciences cognitives >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie > > >]
Garraux, Gaëtan mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > > >]
Mar-2005
Journal of Neurology
Dr Dietrich Steinkopff Verlag
252
3
283-290
Yes (verified by ORBi)
International
0340-5354
Darmstadt
[en] dementia ; Alzheimer ; cerebral activity
[fr] démence sénile ; PET
[en] Different scales can be used to evaluate dementia severity in Alzheimers disease (AD). They do assess different cognitive or functional abilities, but their global scores are frequently in mutual correlation. Functional imaging provides an objective method for the staging of dementia severity. Positron emission tomography was used to assess the relationship between brain metabolism and four dementia scales that reflect a patients global cognitive abilities (mini mental state), caregivers evaluation of cognitive impairment (newly designed scale), daily living functioning (instrumental activities of daily living) and global dementia (clinical dementia rating). We wondered whether different clinical dementia scales would be related to severity of metabolic impairment in the same brain regions, and might reflect impairment of common cognitive processes. 225 patients with probable AD were recruited in a prospective multicentre European study. All clinical scales were related to brain metabolism in associative temporal, parietal or frontal areas. A factorial analysis demonstrated that all scales could be classified in a single factor. That factor was highly correlated to decrease of cerebral activity in bilateral parietal and temporal cortices, precuneus, and left middle frontal gyrus. This finding suggests that global scores for all scales provided similar information on the neural substrate of dementia severity. Capitalizing on the neuroimaging literature, dementia severity reflected by reduced metabolism in posterior and frontal associative areas in AD might be related to a decrease of controlled processes.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; DIMI
Researchers ; Professionals
http://hdl.handle.net/2268/11346
10.1007/s00415-005-0551-3
http://www.springerlink.com/content/vfevq30ee3ca0djh/

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