[en] No consistent cerebral anatomical abnormality has ever been reported in primary focal hand dystonia (FHD). The present voxel-based morphometry study showed a significant bilateral increase in gray matter in the hand representation area of primary somatosensory and, to a lesser extent, primary motor cortices in 36 patients with unilateral FHD compared with 36 controls. The presence of anatomical changes in the perirolandic cortex for the unaffected hand as well as that for the affected hand suggests that these disturbances may be, at least in part, primary.
Disciplines :
Neurology
Author, co-author :
Garraux, Gaëtan ; Université de Liège - ULiège & Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Bauer, Andrew; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Hanakawa, Takashi; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Wu, Tao; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Kansaku, Kenji; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Hallett, M.; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Language :
English
Title :
Changes in brain anatomy in focal hand dystonia
Publication date :
May 2004
Journal title :
Annals of Neurology
ISSN :
0364-5134
eISSN :
1531-8249
Publisher :
Wiley Liss, Inc., New York, United States - New York
NINDS - National Institute of Neurological Disorders and Stroke [US-MD] [US-MD] Horlait-Dapsens Foundations [BE] BAEF - Belgian American Educational Foundation [BE] OTAN - Organisation du traité de l'Atlantique Nord [BE] Fondation Léon Fredericq [BE] F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Cohen LG, Hallett M. Hand cramps: clinical features and electromyographic patterns in a focal dystonia. Neurology 1988;38:1005-1012.
Hallett M. Is dystonia a sensory disorder? Ann Neurol 1995;38:139-140.
Meunier S, Garnero L, Ducorps A, et al. Human brain mapping in dystonia reveals both endophenotypic traits and adaptive reorganization. Ann Neurol 2001;50:521-527.
Zeuner KE, Bara-Jimenez W, Noguchi PS, et al. Sensory training for patients with focal hand dystonia. Ann Neurol 2002;51:593-598.
Bara-Jimenez W, Catalan MJ, Hallett M, et al. Abnormal somatosensory homunculus in dystonia of the hand. Ann Neurol 1998;44:828-831.
Butterworth S, Francis S, Kelly E, et al. Abnormal cortical sensory activation in dystonia: an fMRI study. Mov Disord 2003;18:673-682.
Byrnes ML, Thickbroom GW, Wilson SA, et al. The corticomotor representation of upper limb muscles in writer's cramp and changes following botulinum toxin injection. Brain 1998;121:977-988.
Bhatia KP, Marsden CD. The behavioural and motor consequences of focal lesions of the basal ganglia. Brain 1994;117:859-876.
Maguire EA, Gadian DG, Johnsrude IS, et al. Navigation-related structural change in the hippocampi of taxi drivers. Proc Natl Acad Sci USA 2000;47:4398-4403.
Good CD, Johnsrude I, Ashburner J, et al. A voxel-based morphometric study of ageing in 465 normal adult human brain. Neuroimage 2001;14:21-36.
Yousry TA, Schmid UD, Alkadhi H, et al. Localization of the motor hand area to a knob on the precentral gyrus. A new landmark. Brain 1997;120:141-157.
Geyer S, Schormann T, Mohlberg H, et al. Areas 3a, 3b, and 1 of human primary somatosensory cortex. Part 2. Spatial normalization to standard anatomical space. Neuroimage 2000;11:684-696.
Grefkes C, Geyer S, Schormann T, et al. Human somatosensory area 2: observer-independent cytoarchitectonic mapping, interindividual variability, and population map. Neuroimage 2001;14:617-631.
Molloy FM, Carr TD, Zeuner KE, et al. Abnormalities of spatial discrimination in focal and generalized dystonia. Brain 2003;126:2175-2182.
Burguera JA, Bataller L, Valero C. Action hand dystonia after cortical parietal infarction. Mov Disord 2001;16:1183-1185.
Black KJ, Ongur D, Perlmutter JS. Putamen volume in idiopathic focal dystonia. Neurology 1998;51:819-824.
