Reference : Imaging a cognitive model of apraxia: The neural substrate of gesture-specific cognit...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/11340
Imaging a cognitive model of apraxia: The neural substrate of gesture-specific cognitive processes
English
Peigneux, Philippe mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cognitives > > >]
Van der Linden, Martial mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
Garraux, Gaëtan mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > > >]
Laureys, Steven mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Aerts, Joël mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Del Fiore, Guy [> > > >]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie > >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron > > >]
Salmon, Eric mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > >]
Mar-2004
Human Brain Mapping
Wiley Liss, Inc.
21
3
119-142
Yes (verified by ORBi)
International
1065-9471
New York
[en] apraxia ; upper limb movements ; gesture imitation ; neuropsychological model ; cognitive modelling ; brain imaging ; PET ; statistical parametric mapping
[en] The present study aimed to ascertain the neuroanatomical basis of an influential neuropsychological model for upper limb apraxia [Rothi LJ, et al. The Neuropsychology of Action. 1997. Hove, UK: Psychology Press]. Regional cerebral blood flow was measured in healthy volunteers using (H2O)-O-15 PET during performance of four tasks commonly used for testing upper limb apraxia, i.e., pantomime of familiar gestures on verbal command, imitation of familiar gestures, imitation of novel gestures, and an action-semantic task that consisted in matching objects for functional use. We also re-analysed data from a previous PET study in which we investigated the neural basis. of the visual analysis of gestures. First; we found that two sets of discrete brain areas are predominantly engaged in the imitation of familiar and novel gestures, respectively. Segregated brain activation for novel gesture mutation concur with neuropsychological reports to support the hypothesis that knowledge about the organization of the human body mediates the transition from visual perception to motor execution when imitating novel gestures [Goldenberg Neuropsychologia 1995;35.63-72]. Second, conjunction analyses revealed distinctive neural bases for most of the gesture-specific cognitive processes proposed in this cognitive model of upper limb apraxia. However, a functional analysis of brain imaging data suggested that one single memory store may be used for "to be-perceived" and "to-be-produced" gestural representations, departing from Rothi et al.'s proposal. Based on the above considerations, we suggest and discuss a revised model for upper limb apraxia that might best account for both brain imaging findings and neuropsychological dissociations reported in the apraxia literature. (C) 2004 Wiley-Liss, Inc.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; PAI/IAP Interuniversity Pole of Attraction; Grant Number: P5/04
Researchers ; Professionals
http://hdl.handle.net/2268/11340
10.1002/hbm.10161
http://www3.interscience.wiley.com/journal/107061616/abstract

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