Article (Scientific journals)
Imaging a cognitive model of apraxia: The neural substrate of gesture-specific cognitive processes
Peigneux, Philippe; Van der Linden, Martial; Garraux, Gaëtan et al.
2004In Human Brain Mapping, 21 (3), p. 119-142
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Keywords :
apraxia; upper limb movements; gesture imitation; neuropsychological model; cognitive modelling; brain imaging; PET; statistical parametric mapping
Abstract :
[en] The present study aimed to ascertain the neuroanatomical basis of an influential neuropsychological model for upper limb apraxia [Rothi LJ, et al. The Neuropsychology of Action. 1997. Hove, UK: Psychology Press]. Regional cerebral blood flow was measured in healthy volunteers using (H2O)-O-15 PET during performance of four tasks commonly used for testing upper limb apraxia, i.e., pantomime of familiar gestures on verbal command, imitation of familiar gestures, imitation of novel gestures, and an action-semantic task that consisted in matching objects for functional use. We also re-analysed data from a previous PET study in which we investigated the neural basis. of the visual analysis of gestures. First; we found that two sets of discrete brain areas are predominantly engaged in the imitation of familiar and novel gestures, respectively. Segregated brain activation for novel gesture mutation concur with neuropsychological reports to support the hypothesis that knowledge about the organization of the human body mediates the transition from visual perception to motor execution when imitating novel gestures [Goldenberg Neuropsychologia 1995;35.63-72]. Second, conjunction analyses revealed distinctive neural bases for most of the gesture-specific cognitive processes proposed in this cognitive model of upper limb apraxia. However, a functional analysis of brain imaging data suggested that one single memory store may be used for "to be-perceived" and "to-be-produced" gestural representations, departing from Rothi et al.'s proposal. Based on the above considerations, we suggest and discuss a revised model for upper limb apraxia that might best account for both brain imaging findings and neuropsychological dissociations reported in the apraxia literature. (C) 2004 Wiley-Liss, Inc.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Peigneux, Philippe ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cognitives
Van der Linden, Martial ;  Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Garraux, Gaëtan  ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Laureys, Steven  ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Degueldre, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Aerts, Joël ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Del Fiore, Guy
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Salmon, Eric  ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Language :
English
Title :
Imaging a cognitive model of apraxia: The neural substrate of gesture-specific cognitive processes
Publication date :
March 2004
Journal title :
Human Brain Mapping
ISSN :
1065-9471
eISSN :
1097-0193
Publisher :
Wiley Liss, Inc., New York, United States - New York
Volume :
21
Issue :
3
Pages :
119-142
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
PAI/IAP Interuniversity Pole of Attraction; Grant Number: P5/04
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