Reference : Natural Killer cells - role in local tumor growth and metastasis
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Human health sciences : Oncology
http://hdl.handle.net/2268/113249
Natural Killer cells - role in local tumor growth and metastasis
English
Langers, Inge mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Renoux, Virginie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Thiry, Marc mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Jacobs, Nathalie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Apr-2012
Biologics: Targets and Therapy
Dove Medical Press
Yes (verified by ORBi)
International
1177-5475
1177-5491
Auckland
New Zealand
[en] Natural killer ; tumor ; cytotoxicity
[en] Historically, the name of Natural Killer (NK) cells came from their natural ability to kill tumor cells in vitro. From the seventies to date, accumulating data highlighted the importance of NK cells in host immune response against cancer and in therapy-induced anti-tumor response. The recognition and the lysis of tumor cells by NK cells are regulated by a complex balance of inhibitory and activating signals. This review summarizes NK cell mechanisms to kill cancer cells, their role in host immune responses against tumor growth or metastasis and their implications in anti-tumor immunotherapies via cytokines, antibodies or in combination with other therapies. The regulatory role of NK cells in autoimmunity is also discussed.
Giga-Infection, Immunity and Inflammation ; Giga-Cancer
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Télévie
Researchers ; Students ; General public
http://hdl.handle.net/2268/113249
http://reflexions.ulg.ac.be/CellulesNK

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