ORBi: Servais Anne-Catherine - Capillary electrophoretic and nuclear magnetic resonance studies on the opposite affinity pattern of propranolol enantiomers towards various cyclodextrins

Reference : Capillary electrophoretic and nuclear magnetic resonance studies on the opposite affinit...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/11324

Title :	Capillary electrophoretic and nuclear magnetic resonance studies on the opposite affinity pattern of propranolol enantiomers towards various cyclodextrins
Language :	English
Author, co-author :	Servais, Anne-Catherine [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
	Rousseau, Anne [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
	Fillet, Marianne [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
	Lomsadze, Ketevan [Tbilisi State University > > > >]
	Salgado, Antonio [Centro Nacional de Investigaciones Oncológicas > > > >]
	Crommen, Jacques [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
	Chankvetadze, Bezhan [Tbilisi State University > > > >]
Publication date :	2010
Journal title :	Journal of Separation Science
Publisher :	Wiley-VCH Verlag Gmbh
Volume :	33
Pages :	1617-1624
Audience :	International
ISSN :	1615-9306
e-ISSN :	1615-9314
City :	Weinheim
Country :	Germany
Keywords :	[en] Capillary electrophoresis ; NMR spectroscopy ; Enantiomer migration order ; Separation mechanisms ; Cyclodextrins ; Propranolol
Abstract :	[en] In the present study the migration order of the propranolol enantiomers with various native CDs and neutral and charged CD derivatives was examined in capillary electrophoresis (CE). The reversal of the enantiomer migration order was observed due to sulfation of β-CD on its primary hydroxy groups. The structures of intermolecular selector-selectand temporary diastereomeric associates in solution were elucidated based on 1D rotating frame nuclear Overhauser effect spectroscopy (1D ROESY) experiments. Major structural differences were observed between the propranolol complexes with native β-CD and heptakis(6-O-sulfo)-β-CD.
Funders :	Georgia National Science Foundation (GNSF) ; Merck Research Laboratories ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Permalink :	http://hdl.handle.net/2268/11324

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Article.pdf		Publisher postprint	397.36 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5