Reference : Capillary electrophoretic and nuclear magnetic resonance studies on the opposite affinit...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/11324
Capillary electrophoretic and nuclear magnetic resonance studies on the opposite affinity pattern of propranolol enantiomers towards various cyclodextrins
English
Servais, Anne-Catherine mailto [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Rousseau, Anne mailto [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Fillet, Marianne mailto [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Lomsadze, Ketevan [Tbilisi State University > > > >]
Salgado, Antonio [Centro Nacional de Investigaciones Oncológicas > > > >]
Crommen, Jacques mailto [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Chankvetadze, Bezhan [Tbilisi State University > > > >]
2010
Journal of Separation Science
Wiley-VCH Verlag Gmbh
33
1617-1624
Yes (verified by ORBi)
International
1615-9306
1615-9314
Weinheim
Germany
[en] Capillary electrophoresis ; NMR spectroscopy ; Enantiomer migration order ; Separation mechanisms ; Cyclodextrins ; Propranolol
[en] In the present study the migration order of the propranolol enantiomers with various native CDs and neutral and charged CD derivatives was examined in capillary electrophoresis (CE). The reversal of the enantiomer migration order was observed due to sulfation of β-CD on its primary hydroxy groups. The structures of intermolecular selector-selectand temporary diastereomeric associates in solution were elucidated based on 1D rotating frame nuclear Overhauser effect spectroscopy (1D ROESY) experiments. Major structural differences were observed between the propranolol complexes with native β-CD and heptakis(6-O-sulfo)-β-CD.
Georgia National Science Foundation (GNSF) ; Merck Research Laboratories ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/11324

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Article.pdfPublisher postprint397.36 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.