Capillary electrophoretic and nuclear magnetic resonance studies on the opposite affinity pattern of propranolol enantiomers towards various cyclodextrins
[en] In the present study the migration order of the propranolol enantiomers with various native CDs and neutral and charged CD derivatives was examined in capillary electrophoresis (CE). The reversal of the enantiomer migration order was observed due to sulfation of β-CD on its primary hydroxy groups. The structures of intermolecular selector-selectand temporary diastereomeric associates in solution were elucidated based on 1D rotating frame nuclear Overhauser effect spectroscopy (1D ROESY) experiments. Major structural differences were observed between the propranolol complexes with native β-CD and heptakis(6-O-sulfo)-β-CD.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Servais, Anne-Catherine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Rousseau, Anne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Lomsadze, Ketevan; Tbilisi State University
Salgado, Antonio; Centro Nacional de Investigaciones Oncológicas
Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Chankvetadze, Bezhan; Tbilisi State University
Language :
English
Title :
Capillary electrophoretic and nuclear magnetic resonance studies on the opposite affinity pattern of propranolol enantiomers towards various cyclodextrins
Publication date :
2010
Journal title :
Journal of Separation Science
ISSN :
1615-9306
eISSN :
1615-9314
Publisher :
Wiley-VCH Verlag Gmbh, Weinheim, Germany
Volume :
33
Pages :
1617-1624
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
GNSF - Georgian National Science Foundation [GE] MSD - Merck Sharp and Dohme [BE] F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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