[en] In a multicenter study, FDG-PET images in a population of 29 patients with frontotemporal dementia (FTD) were compared to controls with similar age from each center. A conjunction analysis led to identification of the ventromedial frontopolar cortex as the single region affected in each and every FTD patients. This precise regional metabolic impairment should be integrated with recent neuropsychological researches, such as those showing that the ventromedial frontal cortex is critically involved in decision-making processes based on personal experience, feelings of rightness or social knowledge, processes that are characteristically impaired in FTD. (C) 2003 Elsevier Inc. All rights reserved.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology Radiology, nuclear medicine & imaging Neurosciences & behavior
Author, co-author :
Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Garraux, Gaëtan ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Delbeuck, Xavier; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Kalbe, Elke; Department of Neurology, University of Cologne, and Max-Planck Institute for Neurological Research, Cologne, Germany
Zuendorf, Gerhard; Department of Neurology, University of Cologne, and Max-Planck Institute for Neurological Research, Cologne, Germany
Perani, Daniela; INB-CNR, Universities Vita-Salute HSR and Milano-Bicocca, Scientific Institute HSR, Milano, Italy
Fazio, Ferruccio; INB-CNR, Universities Vita-Salute HSR and Milano-Bicocca, Scientific Institute HSR, Milano, Italy
Herholz, Karl; Department of Neurology, University of Cologne, and Max-Planck Institute for Neurological Research, Cologne, Germany
Language :
English
Title :
Predominant ventromedial frontopolar metabolic impairment in frontotemporal dementia
Publication date :
September 2003
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Academic Press Inc Elsevier Science, San Diego, United States - California
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