Reference : Neural and cognitive bases of upper limb apraxia in corticobasal degeneration
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/11318
Neural and cognitive bases of upper limb apraxia in corticobasal degeneration
English
Peigneux, Philippe mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cognitives > Département des sciences cognitives > > >]
Salmon, Eric mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > >]
Garraux, Gaëtan mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > > >]
Laureys, Steven mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > >]
Willems, Sylvie mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
Dujardin, Kathy [CHRU de Lille > Neurologie > > >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron > > >]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie > >]
Franck, Georges [Université de Liège - ULg > Département des sciences cliniques > Neurologie > >]
Destee, A. [CHRU de Lille > Neurologie > > >]
Van der Linden, Martial mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
9-Oct-2001
Neurology
Lippincott Williams & Wilkins
57
7
1259-1268
Yes (verified by ORBi)
International
0028-3878
Philadelphia
[fr] imitation ; test
[en] OBJECTIVE: To investigate the neural and cognitive bases of upper limb apraxia in corticobasal degeneration (CBD). METHODS: Eighteen patients with CBD underwent a cognitive neuropsychological assessment of apraxia and resting [(18)F]-fluorodeoxyglucose PET scanning. Two complementary measures of apraxia were computed for each modality of gesture production. First, a performance score measured error frequency during gesture execution. Second, as a more stringent test of the integrity of the praxis system, the correction score measured the patient's ability to correct his or her errors on a second attempt. For each measure type, a cut-off score for the presence of apraxia was defined with regard to healthy controls. Using each cut-off score, the regional cerebral glucose metabolism of patients with CBD with apraxia (i.e., performing below cut-off score) was compared with that of patients with CBD without apraxia. RESULTS: Mean performance scores were below normal values in all modalities. Anterior cingulate hypometabolism predominated in patients with CBD who performed below the cut-off performance score. At variance, mean correction scores were below normal values for gesture imitation only. Hypometabolism in superior parietal lobule and supplementary motor area characterized patients with CBD who were unable to correct their errors at the same rate as control subjects did. CONCLUSIONS: Distinct neural networks underlie distinct aspects of the upper limb apraxic deficits in CBD. Extending previous findings of gesture production deficits in CBD, the use of complementary measures of apraxic behavior discloses a visuoimitative upper limb apraxia in CBD, underlain by a metabolic decrease in a parietofrontal neural network.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/11318
http://www.neurology.org/cgi/content/abstract/57/7/1259

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