ORBi: Garraux Gaëtan - Voxel-based distribution of metabolic impairment in corticobasal degeneration

Reference : Voxel-based distribution of metabolic impairment in corticobasal degeneration


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Radiology, nuclear medicine & imaging Human health sciences : Neurology Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/11312

Title :	Voxel-based distribution of metabolic impairment in corticobasal degeneration
Language :	English
Author, co-author :	Garraux, Gaëtan [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > > >]
	Salmon, Eric [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > >]
	Peigneux, Philippe [Université de Liège - ULg > Centre de Recherches du Cyclotron et Département des sciences cognitives > > >]
	Kreisler, Alexandre [Université de Lille > CHRU > Neurologie > >]
	Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Destee, Alain [Université de Lille > CHRU > Neurologie > >]
	Franck, Georges [Université de Liège - ULg > Département des sciences cliniques > Neurologie > >]
Publication date :	Sep-2000
Journal title :	Movement Disorders
Publisher :	John Wiley & Sons
Volume :	15
Issue/season :	5
Pages :	894-904
Audience :	International
ISSN :	0885-3185
Keywords :	[en] Corticobasal degeneration ; Progressive supranuclear palsy ; PET
Abstract :	[en] This report emphasizes the precise topographic distribution of cerebral metabolic impairment in corticobasal degeneration (CBD) and the pathophysiological differences between CBD and progressive supranuclear palsy (PSP). Statistical parametric mapping (SPM96) analysis of 18FDG positron emission tomography (PET) data was performed in 22 patients with CBD compared with 46 healthy subjects (HS) and 21 patients with PSP who were studied at rest. A statistical threshold of p <0.001 was fixed, further corrected for multiple or independent comparisons (p <0.05). In comparison with HS, the metabolic impairment in CBD was asymmetrically distributed in the putamen, thalamus, precentral (Brodmann's area, BA 4), lateral premotor (BA 6/44) and supplementary motor areas (SMA, BA 6), dorsolateral prefrontal (8/9/46) cortex, and the anterior part of the inferior parietal lobe (BA 40) including the intraparietal sulcus (BA 7/40). A similar hypometabolic pattern was observed for most individual analyses. When PSP was compared with CBD, metabolic impairment predominated in the midbrain, anterior cingulate (BA 24/32), and orbitofrontal regions (BA 10). The reverse contrast showed more posterior involvement in CBD (BA 6 and 5/7/40) including SMA. Our data suggest that multiple components of neural networks related to both movement execution and production of skilled movements are functionally disturbed in CBD compared with both HS and PSP.
Research units :	Centre de Recherches du Cyclotron - CRC
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/11312
DOI :	10.1002/1531-8257(200009)15:5<894::AID-MDS1021>3.0.CO;2-S
Other URL :	http://www3.interscience.wiley.com/journal/76508371/abstract

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Garraux_CBD_PSP_FDG_PET_ 2000.pdf		Publisher postprint	726.4 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5