Reference : Comparison of impaired subcortico-frontal metabolic networks in normal aging, subcort...
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/11306
Comparison of impaired subcortico-frontal metabolic networks in normal aging, subcortico-frontal dementia, and cortical frontal demential
English
Garraux, Gaëtan mailto [Université de Liège - ULg > Centre de Recherches du cyclotron et Département des sciences cliniques > Neurologie > > >]
Salmon, Eric mailto [Université de Liège - ULg > Centre de Recherches du cyclotron et Département des sciences cliniques > Neurologie > >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Laureys, Steven mailto [Université de Liège - ULg > Centre de Recherches du cyclotron et Département des sciences cliniques > Neurologie > >]
Franck, Georges [Université de Liège - ULg > Département des sciences cliniques > Neurologie > >]
Aug-1999
Neuroimage
Academic Press Inc Elsevier Science
10
2
149-162
Yes (verified by ORBi)
International
1053-8119
San Diego
[en] Normal aging ; Progressive supranuclear palsy ; Frontotemporal dementia ; PET ; (18)FDG
[en] Normal aging, progressive supranuclear palsy (PSP), and frontotemporal dementia (FTD) are characterized by different degrees of decline in frontal lobe functions. We used (18)FDG-PET and statistical parametric mapping (SPM96) to compare relative subcorticofrontal metabolic impairment at rest in 21 healthy elderly subjects (HES), 20 PSP patients, and 6 FTD patients. When HES were compared to 22 healthy young subjects, widespread decrease in metabolism was observed in bilateral medial prefrontal areas including anterior cingulate cortices, in dorsolateral prefrontal areas, in left lateral premotor area, in Broca's area, and in left insula. In PSP compared to the 43 healthy subjects (HS), we observed subcorticofrontal metabolic impairment including both motor and cognitive neural networks. Impairment of functional connections between midbrain tegmentum and cerebellar, temporal and pallidal regions was demonstrated in PSP as compared to HS. When comparing FTD to HS, glucose uptake was primarily reduced in dorsolateral and ventrolateral prefrontal cortices and in frontopolar and anterior cingulate regions. There was also bilateral anterior temporal, right inferior parietal, and bilateral striatal hypometabolism. Finally, FTD showed more severe striatofrontal metabolic impairment than PSP, while mesencephalothalamic involvement was only observed in PSP. Our data suggest that subcorticofrontal metabolic impairment is distributed in distinct subcorticocortical networks in normal aging, PSP, and FTD. Subcorticofrontal dementia in PSP is related to hypometabolism in discrete frontal areas, which are probably disconnected from certain subcortical structures. The concept of subcortical dementia is reinforced by our data, which show disrupted functional connections between mesencephalon and cerebellar cortex, inferior and medial temporal regions, and pallidum.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/11306
10.1006/nimg.1999.0463
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNP-45KV7YN-5&_user=532038&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=22409aaa5dc40078930afbad139d9a34

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Garraux_AGING_PSP_FTD_FDG_PET_1999.pdfPublisher postprint473.23 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.