Reference : Time course of cranial ultrasound abnormalities after arterial switch operation in ne...
Scientific journals : Article
Human health sciences : Pediatrics
http://hdl.handle.net/2268/112972
Time course of cranial ultrasound abnormalities after arterial switch operation in neonates.
English
Sigler, M. [Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > > > Pediatric Cardiology and Thoracic and Cardiovascular Surgery > > >]
Vazquez-Jimenez, J. F. [Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Pediatric Cardiology and Thoracic and Cardiovascular Surgery > > >]
Grabitz, R. G. [Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > > > Pediatric Cardiology and Thoracic and Cardiovascular Surgery > > >]
Hovels-Gurich, H. H. [Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > > > Pediatric Cardiology and Thoracic and Cardiovascular Surgery > > >]
Messmer, B. J. [Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > > > Pediatric Cardiology and Thoracic and Cardiovascular Surgery > > >]
von Bernuth, G. [Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > > > Pediatric Cardiology and Thoracic and Cardiovascular Surgery > > >]
SEGHAYE, Marie-Christine mailto [Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > Pediatric Cardiology > > >]
Mar-2001
Annals of Thoracic Surgery
Elsevier
71
3
877-80
Yes (verified by ORBi)
International
0003-4975
1552-6259
Amsterdam
The Netherlands
[en] Arteries/surgery ; Echoencephalography ; Heart Septal Defects, Ventricular/surgery ; Humans ; Infant, Newborn ; Postoperative Care ; Prospective Studies ; Time Factors ; Transposition of Great Vessels/surgery ; Vascular Surgical Procedures
[en] BACKGROUND: The object of this study was to investigate the time course and fate of abnormal findings in cranial ultrasound after performing an arterial switch operation in neonates with transposition of the great arteries, and to analyze the relationship to cerebral cell damage. METHODS: Cranial ultrasound was performed prospectively in 35 neonates with transposition of the great arteries before the operation as well as 4 hours, 1, 2, and 3 days, and 1 and 2 weeks postoperatively. Blood levels of neuron-specific enolase, a marker of cerebral cell damage, were determined before, during, and 4 and 24 hours postoperatively. RESULTS: In 17 of 35 neonates (49%), early postoperative cranial ultrasound revealed abnormalities indistinguishable from intraventricular hemorrhage. In 11 neonates findings were transient and were normalized 2 weeks postoperatively, whereas in the remaining 6 neonates there was evidence of resolving hemorrhage. In all neonates there was a rise in neuron-specific enolase blood concentrations during and 4 hours after extracorporal circulation without correlation to sonographic findings. CONCLUSIONS: Enhanced echogenicity of the choroid plexus or dilatation of the cerebral ventricular system is a frequent early postoperative finding that may be caused by transient plexus edema rather than intraventricular hemorrhage and is not related to cerebral cell damage.
http://hdl.handle.net/2268/112972

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