Reference : PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor ...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/112454
PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor prognosis but may also occur in lymphoid malignancies.
English
Duhoux, Francois P [> > > >]
Ameye, Genevieve [> > > >]
Montano-Almendras, Carmen P [> > > >]
Bahloula, Khadija [> > > >]
Mozziconacci, Marie J [> > > >]
Laibe, Sophy [> > > >]
Wlodarska, Iwona [> > > >]
Michaux, Lucienne [> > > >]
Talmant, Pascaline [> > > >]
Richebourg, Steven [> > > >]
Lippert, Eric [> > > >]
Speleman, Frank [> > > >]
HERENS, Christian mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique]
Struski, Stephanie [> > > >]
Raynaud, Sophie [> > > >]
Auger, Nathalie [> > > >]
Nadal, Nathalie [> > > >]
Rack, Katrina [> > > >]
Mugneret, Francine [> > > >]
Tigaud, Isabelle [> > > >]
Lafage, Marina [> > > >]
Taviaux, Sylvie [> > > >]
Roche-Lestienne, Catherine [> > > >]
Latinne, Dominique [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques]
Libouton, Jeanne M [> > > >]
Demoulin, Jean*-Baptiste [> > > >]
Poirel, Helene A [> > > >]
2012
British Journal of Haematology
Blackwell Publishing
156
1
76-88
Yes (verified by ORBi)
0007-1048
1365-2141
Oxford
United Kingdom
[en] The PRDM16 (1p36) gene is rearranged in acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) with t(1;3)(p36;q21), sharing characteristics with AML and MDS with MECOM (3q26.2) translocations. We used fluorescence in situ hybridization to study 39 haematological malignancies with translocations involving PRDM16 to assess the precise breakpoint on 1p36 and the identity of the partner locus. Reverse-transcription polymerase chain reaction (PCR) was performed in selected cases in order to confirm the partner locus. PRDM16 expression studies were performed on bone marrow samples of patients, normal controls and CD34(+) cells using TaqMan real-time quantitative PCR. PRDM16 was rearranged with the RPN1 (3q21) locus in 30 cases and with other loci in nine cases. The diagnosis was AML or MDS in most cases, except for two cases of lymphoid proliferation. We identified novel translocation partners of PRDM16, including the transcription factors ETV6 and IKZF1. Translocations involving PRDM16 lead to its overexpression irrespective of the consequence of the rearrangement (fusion gene or promoter swap). Survival data suggest that patients with AML/MDS and PRDM16 translocations have a poor prognosis despite a simple karyotype and a median age of 65 years. There seems to be an over-representation of late-onset therapy-related myeloid malignancies.
http://hdl.handle.net/2268/112454
10.1111/j.1365-2141.2011.08918.x
(c) 2011 Blackwell Publishing Ltd.

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