Reference : Analytical evaluation of the new Abbott Architect 25-OH vitamin D assay
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/112310
Analytical evaluation of the new Abbott Architect 25-OH vitamin D assay
English
CAVALIER, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
CARLISI, Ignazia mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
BEKAERT, Anne-Catherine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
ROUSSELLE, Olivier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Chapelle, Jean-Paul mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Souberbielle, J. C. [ > > ]
2012
Clinical Biochemistry
Elsevier Science
45
505-508
Yes (verified by ORBi)
International
0009-9120
1873-2933
Tarrytown
NY
[en] vitamin D ; analytical validation ; immunoassay
[en] Objectives: Validation of the Architect 25-OH vitamin D assay.
Design and methods: Determination of repeatability, reproducibility, accuracy profile and 25(OH)-vitamin D2 recovery on native samples. Comparison with DiaSorin Liaison and RIA.
Results and conclusion: Coefficients of variation: b6% (13.6 ng/mL) and 2.2% (78.1 ng/mL). Functional sensitivity: 5 ng/mL. Accuracy profile shows that the method is validated between 13.6 and 78.1 ng/mL. Recovery of 25(OH)D2: 75,8%( 95% CI: 61.9–89.7%). Good correlation with DiaSorin RIA and Liaison b50 ng/mL; above this threshold a systematic positive bias was observed.
http://hdl.handle.net/2268/112310

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