Article (Scientific journals)
SHIP2 et signalisation de l'insuline: quel role dans la pathogenese et le traitement du diabete de type 2?
Schurmans, Stéphane
2003In Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 158 (7-9), p. 335-9
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Keywords :
Animals; Diabetes Mellitus, Type 2/drug therapy/etiology; Humans; Insulin/physiology; Phosphoric Monoester Hydrolases/physiology
Abstract :
[en] Based on the analysis of SHIP2+/- and SHIP2-/- mice showing that the lipid phophatase SHIP2 is an important negative regulator of the insulin pathway, we have suggested that the enzyme is a candidate gene for genetic predisposition to type 2 diabetes, and a potential therapeutic target for the same disease. Two years after, we propose to review these hypothesis in light of recent results from our laboratory, from international collaborations and from competitors in the field.
Disciplines :
Genetics & genetic processes
Biochemistry, biophysics & molecular biology
Author, co-author :
Schurmans, Stéphane  ;  Université Libre de Bruxelles - ULB > IRIBHN
Language :
French
Title :
SHIP2 et signalisation de l'insuline: quel role dans la pathogenese et le traitement du diabete de type 2?
Alternative titles :
[en] SHIP2 and insulin signaling: what is its role in the pathogenesis and treatment of type 2 diabetes?
Publication date :
2003
Journal title :
Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique
ISSN :
0377-8231
Publisher :
Académie Royale de Médecine de Belgique, Bruxelles, Belgium
Volume :
158
Issue :
7-9
Pages :
335-9
Peer reviewed :
Peer Reviewed verified by ORBi
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