Reference : Intrinsic brain activity in altered states of consciousness: how conscious is the defaul...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/11164
Intrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function?
English
Boly, Mélanie mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Phillips, Christophe mailto [Université de Liège - ULg > > Centre de recherches du cyclotron - Dép. d'électric., électron. et informat. (Inst.Montefiore) >]
Tshibanda, Luaba mailto [Centre Hospitalier Universitaire de Liège - CHU > > Imagerie médicale >]
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Schabus, M. [> > > >]
Dang Vu, Thien Thanh [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Moonen, Gustave mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Hustinx, Roland mailto [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
Maquet, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Laureys, Steven [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
2008
Annals of the New York Academy of Sciences
New York Academy of Sciences
1129
119-29
Yes (verified by ORBi)
0077-8923
New York
NY
[en] Animals ; Brain/metabolism/physiology ; Consciousness/physiology ; Consciousness Disorders/physiopathology ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Wakefulness/physiology
[en] Spontaneous brain activity has recently received increasing interest in the neuroimaging community. However, the value of resting-state studies to a better understanding of brain-behavior relationships has been challenged. That altered states of consciousness are a privileged way to study the relationships between spontaneous brain activity and behavior is proposed, and common resting-state brain activity features observed in various states of altered consciousness are reviewed. Early positron emission tomography studies showed that states of extremely low or high brain activity are often associated with unconsciousness. However, this relationship is not absolute, and the precise link between global brain metabolism and awareness remains yet difficult to assert. In contrast, voxel-based analyses identified a systematic impairment of associative frontoparieto-cingulate areas in altered states of consciousness, such as sleep, anesthesia, coma, vegetative state, epileptic loss of consciousness, and somnambulism. In parallel, recent functional magnetic resonance imaging studies have identified structured patterns of slow neuronal oscillations in the resting human brain. Similar coherent blood oxygen level-dependent (BOLD) systemwide patterns can also be found, in particular in the default-mode network, in several states of unconsciousness, such as coma, anesthesia, and slow-wave sleep. The latter results suggest that slow coherent spontaneous BOLD fluctuations cannot be exclusively a reflection of conscious mental activity, but may reflect default brain connectivity shaping brain areas of most likely interactions in a way that transcends levels of consciousness, and whose functional significance remains largely in the dark.
http://hdl.handle.net/2268/11164
10.1196/annals.1417.015

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