Article (Scientific journals)
Responsive corneosurfametry following in vivo skin preconditioning.
Uhoda, Emmanuelle; Goffin, Véronique; Pierard, Gérald
2003In Contact Dermatitis, 49 (6), p. 292-6
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Keywords :
Adult; Dermatitis, Allergic Contact/etiology/physiopathology; Detergents/adverse effects; Electric Capacitance; Female; Forearm; Humans; Immersion; Irritants/adverse effects; Male; Skin/drug effects
Abstract :
[en] Skin is subjected to many environmental threats, some of which altering the structure and function of the stratum corneum. Among them, surfactants are recognized factors that may influence irritant contact dermatitis. The present study was conducted to compare the variations in skin capacitance and corneosurfametry (CSM) reactivity before and after skin exposure to repeated subclinical injuries by 2 hand dishwashing liquids. A forearm immersion test was performed on 30 healthy volunteers. 2 daily soak sessions were performed for 5 days. At inclusion and the day following the last soak session, skin capacitance was measured and cyanoacrylate skin-surface strippings were harvested. The latter specimens were used for the ex vivo microwave CSM. Both types of assessments clearly differentiated the 2 hand dishwashing liquids. The forearm immersion test allowed the discriminant sensitivity of CSM to increase. Intact skin capacitance did not predict CSM data. By contrast, a significant correlation was found between the post-test conductance and the corresponding CSM data. In conclusion, a forearm immersion test under realistic conditions can discriminate the irritation potential between surfactant-based products by measuring skin conductance and performing CSM. In vivo skin preconditioning by surfactants increases CSM sensitivity to the same surfactants.
Disciplines :
Dermatology
Author, co-author :
Uhoda, Emmanuelle ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Goffin, Véronique ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Pierard, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Responsive corneosurfametry following in vivo skin preconditioning.
Publication date :
2003
Journal title :
Contact Dermatitis
ISSN :
0105-1873
eISSN :
1600-0536
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
49
Issue :
6
Pages :
292-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 April 2009

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