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Poster (Scientific congresses and symposiums)
Design of reversibly disulfide core cross-linked polymer micelles
Cajot, Sébastien; Schol, Daureen; Danhier, F. et al.
2011PAI P6/27 Annual Meeting
 

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Keywords :
nanostructured material; self-assembly in solution; micelle; nanomedicine
Abstract :
[en] Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block copolymers are supramolecular core-shell type assemblies of tens of nanometers in diameter. An accumulation of polymer nanocarriers to solid tumours is possible due to the EPR effect. Even if micelles get a high stability in aqueous media, the dissociation of micelles is not always preserved when they are injected in the blood compartment. This work aims at reporting on the design of reversibly cross-linked micelles based on PEO-b-PCL copolymers by introducing disulfide bridges in the micelle core to provide higher stability. Different kinds of macromolecular architectures are employed to study their impact on the micelles and their biological behavior. These new functional copolymers were all successfully micellized, reversibly cross-linked and are stealthy, which show the efficiency of the developed cross-linking process and offer a set of nanocarriers to be tested further, as shown on the first biological tests.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Cajot, Sébastien ;  Université de Liège - ULiège > Centre d'études et de rech. sur les macromolécules (CERM)
Schol, Daureen ;  Université de Liège - ULiège > Biomedical Sciences and Preclinical Department > Laboratory of Histology and Cytology
Danhier, F.;  Université catholique de Louvain (UCL), Brussels > Louvain Drug Research Institute (LDRI) > Pharmaceutics and Drug Delivery
Lautram, N.;  University of Angers (France) > INSERM
Passirani, Catherine;  University of Angers (France) > INSERM
Préat, Véronique;  Université catholique de Louvain (UCL), Brussels > Louvain Drug Research Institute (LDRI) > Pharmaceutics and Drug Delivery
De Pauw-Gillet, Marie-Claire ;  Université de Liège - ULiège > Biomedical Sciences and Preclinical Department > Laboratory of Histology and Cytology
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Design of reversibly disulfide core cross-linked polymer micelles
Publication date :
21 November 2011
Event name :
PAI P6/27 Annual Meeting
Event place :
Leuven, Belgium
Event date :
21/11/2011 - 22/11/2011
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
Commentary :
This poster was presented by Sébastien Cajot
Available on ORBi :
since 07 February 2012

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