Reference : Design of reversibly disulfide core cross-linked polymer micelles
Scientific congresses and symposiums : Poster
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/111249
Design of reversibly disulfide core cross-linked polymer micelles
English
Cajot, Sébastien mailto [Université de Liège - ULg > > Centre d'études et de rech. sur les macromolécules (CERM) >]
Schol, Daureen mailto [University of Liège (ULg) > Biomedical Sciences and Preclinical Department > Laboratory of Histology and Cytology > >]
Danhier, F. [Université catholique de Louvain (UCL), Brussels > Louvain Drug Research Institute (LDRI) > Pharmaceutics and Drug Delivery > >]
Lautram, N. [University of Angers (France) > > INSERM > >]
Passirani, Catherine [University of Angers (France) > > INSERM > >]
Préat, Véronique [Université catholique de Louvain (UCL), Brussels > Louvain Drug Research Institute (LDRI) > Pharmaceutics and Drug Delivery > >]
De Pauw, Marie-Claire mailto [University of Liège (ULg) > Biomedical Sciences and Preclinical Department > Laboratory of Histology and Cytology > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
21-Nov-2011
No
No
National
PAI P6/27 Annual Meeting
21/11/2011 - 22/11/2011
Leuven
Belgium
[en] nanostructured material ; self-assembly in solution ; micelle ; nanomedicine
[en] Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block copolymers are supramolecular core-shell type assemblies of tens of nanometers in diameter. An accumulation of polymer nanocarriers to solid tumours is possible due to the EPR effect. Even if micelles get a high stability in aqueous media, the dissociation of micelles is not always preserved when they are injected in the blood compartment. This work aims at reporting on the design of reversibly cross-linked micelles based on PEO-b-PCL copolymers by introducing disulfide bridges in the micelle core to provide higher stability. Different kinds of macromolecular architectures are employed to study their impact on the micelles and their biological behavior. These new functional copolymers were all successfully micellized, reversibly cross-linked and are stealthy, which show the efficiency of the developed cross-linking process and offer a set of nanocarriers to be tested further, as shown on the first biological tests.
Center for Education and Research on Macromolecules (CERM)
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy
Researchers
http://hdl.handle.net/2268/111249
This poster was presented by Sébastien Cajot

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