Reference : PREDetector: A new tool to identify regulatory elements in bacterial genomes
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/1112
PREDetector: A new tool to identify regulatory elements in bacterial genomes
English
Hiard, Samuel mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Marée, Raphaël mailto [Université de Liège - ULg > > GIGA-Management : Plateforme bioinformatique >]
Colson, Séverine mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Hoskisson, Paul A. [University of Aberdeen > Department of Molecular and Cell Biology, > > >]
Titgemeyer, Fritz [Friedrich-Alexander-Universität Erlangen-Nürnberg > > Lehrstuhl für Mikrobiologie > >]
van Wezel, Gilles P. [Leiden University > Leiden Institute of Chemistry > Microbial Development > >]
Joris, Bernard mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Wehenkel, Louis mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Rigali, Sébastien mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Jun-2007
Biochemical and Biophysical Research Communications
Academic Press Inc Elsevier Science
357
4
861-864
Yes (verified by ORBi)
International
0006-291X
San Diego
[en] regulon prediction ; transcriptional regulation ; regulatory networks ; position weight matrix ; DNA-binding motif
[en] In the post-genomic area, the prediction of transcription factor regulons by position weight matrix-based programmes is a powerful approach to decipher biological pathways and to modelize regulatory networks in bacteria. The main difficulty once a regulon prediction is available is to estimate its reliability prior to start expensive experimental validations and therefore trying to find a way how to identify true positive hits from an endless list of potential target genes of a regulatory protein. Here we introduce PREDetector (Prokaryotic Regulatory Elements Detector), a tool developed for predicting regulons of DNA-binding proteins in bacterial genomes that, beside the automatic prediction, scoring and positioning of potential binding sites and their respective target genes in annotated bacterial genomes, it also provides an easy way to estimate the thresholds where to find reliable possible new target genes. PREDetector can be downloaded freely at http://www.montefiore.ulg.ac.be/-hiard/PreDetector (c) 2007 Published by Elsevier Inc.
Systmod
http://hdl.handle.net/2268/1112
10.1016/j.bbrc.2007.03.180
http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=17451648&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0006-291X(07)00684-5
http://www.montefiore.ulg.ac.be/~hiard/PreDetector/

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
hiard2007-PREDetector-elsevier.pdfNo commentaryPublisher postprint204.12 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.