Reference : Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, pl...
Scientific journals : Article
Human health sciences : General & internal medicine
Human health sciences : Public health, health care sciences & services
http://hdl.handle.net/2268/111183
Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study
English
Bruyère, Olivier mailto [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Zegels, Brigitte [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Leonori, Lorenzo mailto [Centre Hospitalier Universitaire de Liège - CHU > BRULL > > >]
Rabenda, Véronique mailto [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Janssen, A. [ > > ]
Bourges, C. [ > > ]
Reginster, Jean-Yves mailto [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
2012
Complementary Therapies in Medicine
Harcourt Brace & Company Ltd.
20
124-130
Yes (verified by ORBi)
International
0965-2299
[en] Joint ; Nutrition ; Collagen hydrolysate ; Pain ; Randomized controlled study
[en] Objective: Evaluation of the efficacy and safety of a food supplement made of collagen
hydrolysate 1200 mg/day versus placebo during 6 months, in subjects with joint pain at the
lower or upper limbs or at the lumbar spine.
Design: Comparative double-blind randomized multicenter study in parallel groups.
Setting: 200 patients of both genders of at least 50 years old with joint pain assessed as
≥30 mm
on a visual analogical scale (VAS).
Intervention: Collagen hydrolysate 1200 mg/day or placebo during 6 months.
Main outcome measure: Comparison of the percentage of clinical responder between the active
collagen hydrolysate group and the placebo group after 6 months of study. A responder subject
was defined as a subject experiencing a clinically significant improvement (i.e. by 20% or more)
in the most painful joint using the VAS score. All analyses were performed using an intent-totreat
procedure.
Results: At 6 months, the proportion of clinical responders to the treatment, according to
VAS scores, was significantly higher in the collagen hydrolysate (CH) group 51.6%, compared
to the placebo group 36.5% (p < 0.05). However, there was no significant difference between
groups at 3 months (44.1% vs. 39.6%, p = 0.53). No significant difference in terms of security
and tolerability was observed between the two groups.
Conclusions: This study suggests that collagen hydrolysate 1200 mg/day could increase the number
of clinical responders (i.e. improvement of at least 20% on the VAS) compared to placebo.
More studies are needed to confirm the clinical interest of this food supplement.
Nutraveris
http://hdl.handle.net/2268/111183

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