Reference : Serial translocation by means of circular intermediates underlies colour sidedness in...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/111012
Serial translocation by means of circular intermediates underlies colour sidedness in cattle.
English
Durkin, Keith mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Coppieters, Wouter mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Drogemuller, Cord [> > > >]
Ahariz, Naïma mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Cambisano, Nadine mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Druet, Tom mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Fasquelle, Corinne mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine]
Haile, Aynalem [> > > >]
Horin, Petr [> > > >]
Huang, Lusheng [> > > >]
Kamatani, Yohichiro [> > > >]
Karim, Latifa mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire]
Lathrop, Mark [> > > >]
Moser, Simon [> > > >]
Oldenbroek, Kor [> > > >]
Rieder, Stefan [> > > >]
Sartelet, Arnaud mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Solkner, Johann [> > > >]
Stalhammar, Hans [> > > >]
Zelenika, Diana [> > > >]
Zhang, Zhiyan [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Leeb, Tosso [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Charlier, Carole mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
2-Feb-2012
Nature
Nature Publishing Group
482
7383
81-4
Yes (verified by ORBi)
International
0028-0836
1476-4687
Basingstoke
United Kingdom
[en] Colour sidedness is a dominantly inherited phenotype of cattle characterized by the polarization of pigmented sectors on the flanks, snout and ear tips. It is also referred to as 'lineback' or 'witrik' (which means white back), as colour-sided animals typically display a white band along their spine. Colour sidedness is documented at least since the Middle Ages and is presently segregating in several cattle breeds around the globe, including in Belgian blue and brown Swiss. Here we report that colour sidedness is determined by a first allele on chromosome 29 (Cs(29)), which results from the translocation of a 492-kilobase chromosome 6 segment encompassing KIT to chromosome 29, and a second allele on chromosome 6 (Cs(6)), derived from the first by repatriation of fused 575-kilobase chromosome 6 and 29 sequences to the KIT locus. We provide evidence that both translocation events involved circular intermediates. This is the first example, to our knowledge, of a phenotype determined by homologous yet non-syntenic alleles that result from a novel copy-number-variant-generating mechanism.
Researchers ; Professionals
http://hdl.handle.net/2268/111012
10.1038/nature10757
http://reflexions.ulg.ac.be/RobeBBB

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