Reference : Trypsin-like activity and thromboxane release in adult respiratory distress syndrome.
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/110962
Trypsin-like activity and thromboxane release in adult respiratory distress syndrome.
English
Deby-Dupont, Ginette [Université de Liège - ULg > > Centre de l'Oxygène : recherche et développement > >]
Pincemail, Joël mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Faymonville, Marie-Elisabeth mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Braun, Marc [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation > >]
Deby, Christiane mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service administration des patients >]
Goutier, R. [> > > >]
Lamy, Maurice mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Franchimont, P. [> > > >]
1986
Prostaglandins
Elsevier Science
32
1
106-10
Yes (verified by ORBi)
International
0090-6980
New York
NY
[en] Clinical Enzyme Tests ; Humans ; Laboratory Techniques and Procedures ; Peptide Hydrolases/blood ; Radioimmunoassay/methods ; Respiratory Distress Syndrome, Adult/blood/diagnosis/enzymology ; Risk ; Spectrophotometry/methods ; Thromboxanes/blood ; Trypsin/blood
[en] Plasmatic immunoreactive trypsin (IRT), thromboxane and trypsin-like enzymatic activity were measured in 117 patients at risk of developing adult respiratory distress syndrome (ARDS) (53 multiple injury, 30 abdominal surgery, 17 acute pancreatitis, 12 burnt and 5 disseminated intravascular coagulation patients). 69 of these patients developed ARDS. Immunoreactive trypsin and thromboxane were measured by radio-immuno-assay and trypsin-like enzymatic activity by spectrophotometry, using a specific chromogenic substrate. Mean IRT value was 675 ng/ml in ARDS and 265 ng/ml in non ARDS patients (p less than 0.05). Mean IRT value was 685 ng/ml in septic and 170 ng/ml in non septic patients (p less than 0.01). An abnormal trypsin-like enzymatic activity was measured in 26 ARDS patients. In 60 patients (37 ARDS and 23 non ARDS), thromboxane appeared in plasma simultaneously or about 24 hours after the beginning of IRT release. The importance of thromboxane release parallels the intensity of IRT. Originating from pancreas, trypsin can appear in plasma either by absorption from gastrointestinal tract or after pancreatic ischemia.
http://hdl.handle.net/2268/110962

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