ORBi: Deby-Dupont Ginette - Trypsin-like activity and thromboxane release in adult respiratory distress syndrome.

Reference : Trypsin-like activity and thromboxane release in adult respiratory distress syndrome.


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Anesthesia & intensive care
	To cite this reference:	http://hdl.handle.net/2268/110962

Title :	Trypsin-like activity and thromboxane release in adult respiratory distress syndrome.
Language :	English
Author, co-author :	Deby-Dupont, Ginette [Université de Liège - ULg > > Centre de l'Oxygène : recherche et développement > >]
	Pincemail, Joël [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
	Faymonville, Marie-Elisabeth [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
	Braun, Marc [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation > >]
	Deby, Christiane [Centre Hospitalier Universitaire de Liège - CHU > > Service administration des patients >]
	Goutier, R. [> > > >]
	Lamy, Maurice [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
	Franchimont, P. [> > > >]
Publication date :	1986
Journal title :	Prostaglandins
Publisher :	Elsevier Science
Volume :	32
Issue/season :	1
Pages :	106-10
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0090-6980
City :	New York
Country :	NY
Keywords :	[en] Clinical Enzyme Tests ; Humans ; Laboratory Techniques and Procedures ; Peptide Hydrolases/blood ; Radioimmunoassay/methods ; Respiratory Distress Syndrome, Adult/blood/diagnosis/enzymology ; Risk ; Spectrophotometry/methods ; Thromboxanes/blood ; Trypsin/blood
Abstract :	[en] Plasmatic immunoreactive trypsin (IRT), thromboxane and trypsin-like enzymatic activity were measured in 117 patients at risk of developing adult respiratory distress syndrome (ARDS) (53 multiple injury, 30 abdominal surgery, 17 acute pancreatitis, 12 burnt and 5 disseminated intravascular coagulation patients). 69 of these patients developed ARDS. Immunoreactive trypsin and thromboxane were measured by radio-immuno-assay and trypsin-like enzymatic activity by spectrophotometry, using a specific chromogenic substrate. Mean IRT value was 675 ng/ml in ARDS and 265 ng/ml in non ARDS patients (p less than 0.05). Mean IRT value was 685 ng/ml in septic and 170 ng/ml in non septic patients (p less than 0.01). An abnormal trypsin-like enzymatic activity was measured in 26 ARDS patients. In 60 patients (37 ARDS and 23 non ARDS), thromboxane appeared in plasma simultaneously or about 24 hours after the beginning of IRT release. The importance of thromboxane release parallels the intensity of IRT. Originating from pancreas, trypsin can appear in plasma either by absorption from gastrointestinal tract or after pancreatic ischemia.
Permalink :	http://hdl.handle.net/2268/110962

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